Mohammad Ebrahim Bahram - Ph.D. Students in Sports Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.
Roghayyeh Afroundeh - Associate Professor of Sports Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.
Mohammad Javad Pourvaghar - Associate Professor, Department of Physical Education and Sport Sciences, Faculty of Humanities, University of Kashan, Kashan, Iran.
Farnaz Seify Skishahr - Associate Professor of Sports Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.
Leila Katebi - Assistant Professor, Department of Pediatrics, School of Medicine Bu'ali Hospital, Ardabil University of Medical Sciences, Ardabil, Iran.
Ozkan Isik - Associate Professor, Faculty of sport Sciences, Balikesir University, Balikesir, Turkey

Objective: This study aimed to investigate the effect of ۸ weeks combined exercise and consumption of Mulberry leaf extract on the serum levels of inflammatory and atherosclerosis indicators in elderly men with type ۲ diabetes mellitus (T۲DM). Materials and Methods: ۴۰ elderly men T۲DM aged between ۶۵ to ۷۰ years old were purposefully selected and randomly divided into five equal groups (training, supplement, training+ supplement, placebo, and control). A daily dose of ۱۰۰۰ mg Mulberry leaf extract, ۳ times a day, was used for ۲ months by the supplement group. Training groups performed combined exercises for eight weeks, each week three sessions of ۹۰ minutes. Results: The results showed that the amount of salusin-β and interleukin-۶ in the training, training + supplement and supplement groups decreased significantly at the end of the study; Meanwhile, the level of salusin-α increased significantly in the training (P= ۰.۰۰۱), training + supplement (P= ۰.۰۰۱) and supplement (P= ۰.۰۱) groups. Also, the results of the covariance analysis showed that the amount of salusin-β and interleukin ۶ were lower (P= ۰.۰۰۱), and the level of salusin-α was higher significantly in the training (P= ۰.۰۰۱), training +supplement (P= ۰.۰۰۱), and supplement (P= ۰.۰۰۱) groups compared to the control groups. Conclusion: It seems that the consumption of Mulberry leaf extract, and combined exercises, is effective in controlling the inflammatory indicators and atherosclerosis related to diabetes in the T۲DM elderly.   Corresponding Author: Roghayyeh Afroundeh View Orcid in Profile You can search for this author in PubMed     Google Scholar Profile

Interleukin ۶, Salusin-α, Salusin-β, Diabetes, Elderly