Mehrdad Malekshoar - Associated Professor of Anesthesiology, Intensive Care fellowship, Anesthesiology & Critical Care and Pain Management Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
Pourya Adibi - Assistant Professor of Anesthesiology, Intensive Care fellowship, Anesthesiology & Critical Care and Pain Management Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Kaveh Hedayati Emami - Department of Anesthesiology & Critical Care, Tehran university of Medical Sciences, Tehran, Iran
Majid Vatankhah - Associated Professor of Anesthesiology, Intensive Care fellowship, Anesthesiology & Critical Care and Pain Management Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

Background: Hemodynamic changes during laparoscopic surgery are important categories in laparoscopic cholecystectomy. Therefore, the aim of this study was to evaluate the effect of oral clonidine on hemodynamic status during laparoscopic cholecystectomy. Method: In this randomized double-blind clinical trial study, ۵۰ patients with class I and II anesthesia underwent laparoscopic cholecystectomy. Patients were randomly divided into oral clonidine and control groups. Systolic and diastolic blood pressure, mean arterial pressure (MAP) and intraoperative heart rate were recorded. Results: The results showed that in the third and fourth periods, a significant difference was observed in the mean systolic blood pressure between the two groups (P <۰.۰۵). Mean diastolic blood pressure was significantly different between the two groups only in the fourth period (P <۰.۰۵) and was lower in the clonidine group than the control group. In the clonidine group, the mean trend of systolic and diastolic blood pressure was significant from the first ۳۰ minutes to the fifth ۳۰ minutes (P <۰.۰۰۱). But in the control group was not significant (P = ۰.۱۳۷). The results showed that the mean heart rate between The control group and clonidine were not significant, but in the clonidine group the heart rate increased up to the second ۳۰ minutes but then decreased (P <۰.۰۵). In the control group the heart rate increased up to the second ۳۰ minutes but it has fluctuated since then. Conclusion: The results of the present study showed that oral clonidine was able to stabilize hemodynamics during laparoscopic cholecystectomy. It seems that the use of oral clonidine in laparoscopic cholecystectomy can stabilize hemodynamic symptoms during surgery.

Clonidine Hemodynamic symptoms, Cholecystectomy, Laparoscopy.