Assessment of Machine Learning Approaches to Predict in-Hospital Mortality in Patients Underwent Prosthetic Heart Valve Replacement Surgery

  • سال انتشار: 1402
  • محل انتشار: مجله علمی پژوهشی دانشگاه علوم پزشکی زنجان، دوره: 31، شماره: 146
  • کد COI اختصاصی: JR_ZUMS-31-146_001
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 147
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نویسندگان

Maryam Shojaeifard

Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

Hassan Ahangar

Dept. of Cardiology, Mousavi Hospital, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

Sepehr Gohari

Student Research Center, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

Mehrdad Oveisi

Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King’s College London, London, United Kingdom

Majid Maleki

Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

Tara Reshadmanesh

Student Research Center, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

Shahram Arsang-Jang

Dept. of Biostatistics, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

Mahsa Mahjani

School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Mozhgan Pourkeshavarz

Dept. of Biomedical and Health Informatics, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, Iran

Ghasem Hajianfar

Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, Geneva, Switzerland

Saeedeh Mazloomzadeh

Dept. of Biomedical and Health Informatics, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, Iran

Isaac Shiri

Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, Geneva, Switzerland

Sheida Gohari

Dept. of Systems Science and Industrial Engineering, State University of New York at Binghamton, Binghamton, New York, United States

چکیده

Background and Objective: Machine learning and artificial intelligence are useful tools to analyze data with multiple variables. It has been shown that the prediction models obtained by Machine learning have better performance than the conventional statistical methods. This study was aimed to assess the risk factors and determine the best machine learning prediction model/s for in-hospital mortality among patients who underwent prosthetic valve replacement surgery. Materials and Methods: In this retrospective cross-sectional study, patient’s pre-operative, intra-operative and post-operative data underwent univariate analysis. Feature importance determination was carried out using algorithms including principal component analysis (PCA), support vector machine (SVM), random forest (RF) model-based, and recursive feature elimination (RFE).  Then, ۱۳ machine learning classifiers were implemented for in-hospital prediction model. Results: The In-hospital mortality rate was ۶.۳۶%. Data from ۲۴۵۵ patients underwent final analysis. The machine learning results revealed that among pre-operative features, Adaptive boost (AB) and RF classifiers (AUC: ۰.۸۲±۰.۰۳۳; ۰.۷۸±۰.۰۲۸, respectively); among intra-operative features, AB and K-nearest neighbors (KNN) classifiers (AUC: ۰.۶۸±۰.۰۱۴); among postoperative features, AB and RF classifiers (AUC: ۰.۹±۰.۱; ۰.۸۸±۰.۰۹۵, respectively); and among all features, AB and LR classifiers (AUC: ۰.۹۳±۰.۰۴۹; ۰.۹۳±۰.۰۵۵, respectively) had the best performance in prediction of in-hospital mortality. Conclusion: The AB classifier was determined as the best model in prediction of in-hospital mortality in all ۴ datasets.

کلیدواژه ها

Prosthetic valve replacement, In-hospital mortality, Risk factor, Machine learning

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