The Effects of the Obesity Paradox and In-Hospital and One-Year Outcomes in Patients With ST Elevation Myocardial Infarction (STEMI): Results From a STEMI Registry
- سال انتشار: 1402
- محل انتشار: مجله آریا آترواسکلروز، دوره: 19، شماره: 4
- کد COI اختصاصی: JR_RYA-19-4_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 74
نویسندگان
Cardiovascular Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
Cardiovascular Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
Cardiovascular Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
Cardiovascular Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
Cardiovascular Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
Cardiovascular Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
Cardiovascular Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
Cardiovascular Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
چکیده
Background: Obesity is strongly associated with increased cardiovascular diseases (CVD) and cardiovascular risk factors, such as diabetes mellitus, hypertension, and dyslipidemia. However, numerous studies have suggested the existence of an “obesity paradox” in which overweight and mildly obese patients often exhibit a better outcome than their leaner counterparts. Therefore, this study aimed to characterize the association between BMI and in-hospital and one-year outcomes.Methods: This hospital-based research was conducted as a part of the Kermanshah STEMI Registry. Following the application of inclusion criteria, a total of ۲,۳۹۷ STEMI patients were evaluated. The data were collected using a standardized case report developed by the European Observational Registry Program (EORP). Body mass index (BMI) (kg/m۲) was classified into underweight (< ۱۸.۵), normal weight (۱۸.۵–۲۴.۹), overweight (۲۵–۲۹.۹), class I/mild obese (۳۰–۳۴.۹), and class II/extreme obese (≥۳۵) categories. The independent predictors of the in-hospital and one-year outcomes were assessed using multivariable logistic regression models. Results: Out of the ۲۳۹۷ patients, ۴۳ (۱.۷۹%) were underweight, ۹۳۴ (۳۸.۹۷%) were normal, ۱۰۳۸ (۴۳.۳۰%) were overweight, ۳۲۲ (۱۳.۴۳%) were class I obese, and ۶۰ (۲.۵۰%) were class II obese. The results of the crude analysis showed that class I obesity was protective against CV death (OR ۰.۵۰; ۹۵% CI ۰.۳۰-۰.۸۴), MACE۳ (MI, stroke, and death) (OR ۰.۴۷; ۹۵% CI ۰.۲۹-۰.۷۶), and MACE۵ (MACE۳ plus unstable angina and heart failure) (OR ۰.۵۹; ۹۵% CI ۰.۴۴-۰.۷۹). Conclusions: Multivariate adjustment eliminated the protective effect of class I obesity against death and MACE events. Therefore, it is possible that this protective effect does not exist and instead reflects the impact of confounding variables such as age.کلیدواژه ها
Myocardial Infarction, Registry, BMI, Iran, Obesityاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.