Evaluation of Biological Markers in Children's Cerebrospinal Fluid with Bacterial and Viral Meningitis
- سال انتشار: 1402
- محل انتشار: مجله بین المللی آزمایشگاه پزشکی، دوره: 10، شماره: 3
- کد COI اختصاصی: JR_JIML-10-3_003
- زبان مقاله: انگلیسی
- تعداد مشاهده: 239
نویسندگان
Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
Student Research Committee, Department of Midwifery, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
Department of Clinical Science, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Department of Basic Sciences, Payame Noor University, Tehran, Iran
Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Department of Virology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
Department of Veterinary Sciences, Garmsar Branch, Islamic Azad University, Garmsar, Iran
Iranian Social Security Organization, Kerman, Iran
Department of Laboratory Medicine, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده
Background and Aims: Cerebrospinal fluid (CSF) and blood biomarkers are widely evaluated as diagnostic tools to distinguish between bacterial meningitis and viral meningitis in emergency laboratory tests. So, this aimed to examine the levels of diagnostic parameters in blood and CSF to discriminate between bacterial and viral meningitis in young children referred to Khoy Hospital. Materials and Methods: A total of ۱۰۱ young children with meningitis were enrolled in this prospective study. The diagnosis of bacterial and viral meningitis was based on clinical features and laboratory findings. Results: Of the ۱۰۱ patients with meningitis, ۱۸ (۱۷.۸۲%) were bacterial, and ۸۳ (۸۲.۱۷%) were viral meningitis. The levels of CSF glucose and CSF/blood glucose ratio were significantly lower in the bacterial meningitis group than in the viral meningitis group (p < ۰.۰۱). In contrast, white blood cells count, CSF protein, interleukin-۶, C-reactive protein, and ferritin levels were significantly higher in patients with bacterial meningitis compared to viral meningitis (p < ۰.۰۱). However, there was no difference between viral and bacterial meningitis groups concerning mean serum glucose. Conclusion: This study suggests that decreased CSF glucose and CSF/blood glucose ratio and increased white blood cells count, CSF protein, ferritin, interleukin-۶, and C-reactive protein combined with clinical symptoms can help better diagnosis of bacterial meningitis, especially in comparison with viral meningitis.کلیدواژه ها
Bacterial meningitis, Biological marker, Cerebrospinal fluid, Viral meningitisاطلاعات بیشتر در مورد COI
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