Ameneh Abtahian - Department of Obstetrics and Gynecology, School of Medicine, Shahid Beheshti University Of Medical Sciences, Tehran, Iran
Behzad Rezaei - Laparascopy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Gholamreza Moradpour - Laparascopy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Ladan Aghakhani - Laparascopy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Avkan Aghapoor - Iranian Hospital Dubai, Iranian Red Crescent Society, Dubai, United Arab Emirates
Seyed Hesamaddin Banihashemi - Department of surgery, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
Saeideh Izadi - Laparascopy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Zahra Mohammadi - Laparascopy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Neda Haghighat - Laparoscopy Research Center, Shiraz University of medical sciences, Shiraz, Iran

Background: Obesity is associated with developing polycystic ovary syndrome (PCOS). The present study investigated whether weight loss after bariatric surgery could improve symptoms and related hormones in women with morbid obesity.Methods: In a retrospective observational study, ۵۰ women aged ۱۸-۴۰ years with body mass index (BMI)=۴۲.۳ kg/m۲ who underwent laparoscopic Roux-en-Y gastric bypass (RYGB) were enrolled. Evaluation of anthropometric data, serum testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), fasting plasmaglucose (FPG), and lipid profile were measured preoperatively and at ۱-year follow-upResults: Of ۵۰ women, ۳۲ (۶۴%) women were diagnosed to have PCOS. The mean BMI at ۱-year follow-up was ۲۷.۰۵ kg/m۲. Hirsutism and irregular menstruation resolved entirely among ۶۸.۸% (۱۱/۱۶) and ۱۰۰% (۱۸/۱۸) at ۱-year follow-up. There was a significant decrease in total serum testosterone (۲.۱±۰.۲ to ۰.۹±۰.۱ ng/mL) and LH (۸.۵±۳.۳۶ to ۵.۰۲±۲.۴ mIU/mL) at ۱-year follow-up, whether changes in levels of serum FSH, PRL were not significant.Conclusion: Bariatric surgery was effective in weight loss and improvement of PCOS symptoms and related hormones in women with morbid obesity. Thus, women with PCOS and morbid obesity should be eligible for bariatric surgery.

Polycystic ovary syndrome, Obesity, Bariatric surgery, Weight Loss, Iran