Adjustment of a Fibrosis Marker, Pro-Inflammatory Cytokines, and IgE in Asthmatic Animals
- سال انتشار: 1402
- محل انتشار: فصلنامه پزشکی شخصی، دوره: 8، شماره: 30
- کد COI اختصاصی: JR_PMJ-8-30_005
- زبان مقاله: انگلیسی
- تعداد مشاهده: 167
نویسندگان
Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran
Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Khomein University of Medical Sciences, Khomein, Iran
Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Department of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Department of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
چکیده
Background: A lot of patients are suffering from asthma. For decreasing the asthma symptoms, we studied the effects of conditioned medium (CM) of human amniotic membrane mesenchymal stem cells (hAM-MSCs) as a source of anti-inflammatory cytokines on splenocyte and lung tissue of asthmatic Balb/c mice.Methods: Forty mice were categorized into four groups; ovalbumin (OVA)-induced asthma, CM-treated asthma, DMEM (Dulbecco's Modified Eagle Medium)-treated asthma, and saline control. Each group received related treatment. The lung alpha-smooth muscle actin (α-SMA) and splenocyte inflammatory cytokines and IgE were examined through Western blot analysis.Results: Western blot showed α-SMA overexpression in the OVA and DMEM groups compared with the saline group. CM therapy could significantly reverse it compared with OVA and OVA+DMEM categories by elevating IL-۱۰ and IFN-γ and reducing IL-۴, IgE, and TGF-β .Conclusion: CM treatment could improve asthma symptoms by adjusting α-SMA in lung tissue and pro-inflammatory cytokines and IgE in splenocytes.کلیدواژه ها
Asthma, Alpha-smooth muscle actin, Mesenchymal stem cellاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.