Effect of vitamin D on Helicobacter pylori infection and eradication: An updated systematic review and meta‐analysis
- سال انتشار: 1402
- محل انتشار: تازه های پزشکی بالینی، دوره: 2، شماره: 3
- کد COI اختصاصی: JR_NCLIN-2-3_006
- زبان مقاله: انگلیسی
- تعداد مشاهده: 95
نویسندگان
Department of Community Medicine and Behavioural Sciences, Faculty of Medicine, Kuwait University, Kuwait
Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran
Besat Hospital, Kurdistan University of Medical Sciences, Sanandaj, Iran
Social Determinants of Health Research, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
چکیده
Background: Various studies that have examined the association between Helicobacter pylori (H pylori) and vitamin D (۲۵-hydroxyvitamin D [۲۵(OH)D]) have reported different and sometimes controversial results.Objectives: Therefore, this systematic review and meta-analysis was performed to investigate the relationship between vitamin D and H pylori infection and its eradication.Methods: Observational studies published in English were searched in PubMed, Scopus, and ISI databases until ۱ August ۲۰۲۱. The standardized mean difference (SMD) was used to evaluate the probability ratio of H pylori infection and its eradication in the group with low vitamin D levels and the control group. Pooled estimation was calculated by random effects model. Heterogeneity was assessed by Cochran's Q test and I۲ index.Results: Twelve studies were analyzed in this meta-analysis, and the results showed that the level of ۲۵(OH)D in H pylori‐positive patients was significantly lower than those without infection (SMD= -۰.۶۶ ng/mL, ۹۵% CI: -۰.۹۹, -۰.۳۳, P< ۰.۰۰۱). Also, the level of ۲۵(OH)D in H pylori successful eradication individuals was significantly higher than those with unsuccessful eradication (SMD=۱.۵۳ ng/mL, ۹۵%CI: ۱.۳۴-۱.۷۱, P< ۰.۰۰۱).Conclusion: There is a significant relationship between vitamin D levels and H pylori infection and its eradication. Therefore, it is necessary to pay attention to the vitamin D level in treating H pylori infection.کلیدواژه ها
Helicobacter pylori, eradication, Vitamin Dاطلاعات بیشتر در مورد COI
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