Ramin Ghorbani-Vaghei - Bu-Ali Sina University
Hassan Sanati - Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, ۶۵۱۷۸۳۸۶۸۳, Iran
Sedigheh Alavinia - Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, ۶۵۱۷۸۳۸۶۸۳, Iran

Substituted pyrroles are an essential class of heterocyclic compounds. In this research, an efficient and eco-friendly method has been developed for the synthesis of pyrrole derivatives from the reaction of ۲,۵-hexanedione and primary amines. Magnetic nanoparticles supported on functionalized. ۷-aminonaphthalene-۱,۳-disulfonic acid-functionalized. silica (Fe۳O۴@SiO۲@Propyl–ANDSA) has been investigated as a novel catalyst in this reaction. Herein, a novel catalyst was developed for an efficient and environmentally friendly synthesis of pyrrole in excellent yields. It should also be noted that Fe۳O۴@SiO۲@Propyl–ANDSA as reaction catalyst could be recovered quickly and reused for several times without any decrease in efficiency. With its operational simplicity, green nature, and high yields the reaction will be acting as an attractive alternative for the synthesis of substituted pyrroles.

Fe۳O۴@SiO۲@Propyl-ANDSA, Heterocyclic compounds, Pyrroles, Functionalized silica