Therapeutic Effects of High Dose Intravenous Prednisolone on Methanol Induced Toxic Optic Neuropathy

  • سال انتشار: 1393
  • محل انتشار: مجله سم شناسی پزشکی آسیا اقیانوسیه، دوره: 3، شماره: 0
  • کد COI اختصاصی: JR_PJMT-3-0_025
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 60
دانلود فایل این مقاله

نویسندگان

Mojtaba Abrishami

Eye Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Mohammad Abrishami

Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran

چکیده

Background: The effects of high dose steroids for the treatment of methanol optic neuropathy was evaluated in this study. Methods: In an interventional case series, ۹ patients with a history of sudden visual loss after an ingestion of homemade alcoholic beverages were included in the study. The patients received ۲۵۰ mg intravenous methyl prednisolone every ۶ hours for ۴ days continued with oral prednisolone at ۱ mg/Kg for ۱۰ days. Best corrected visual acuity (BCVA), optical coherent tomography (OCT), fundus photo, and a complete ophthalmologic exam of the patients were taken before the treatment and ۳ months after treatment. Six of them referred before ۴۸ hours and ۳ after ۷۲ hours. Results: All patients were men. The mean age was ۲۴.۶۸ ± ۴.۲ years.  In those who referred before ۴۸ hours, the mean BCVA before the treatment was ۰.۸۶ ± ۰.۰۸ in the right eye (RE) and ۰.۹۳ ± ۰.۱ in the left eye (LE) using the logMAR scale. Four patients showed nerve fiber layer edema as a white density in peripapillary area. After treatment, the mean BCVA in the RE was ۰.۳۳ ± ۰.۱۸ and ۰.۲۹ ± ۰.۲ in the LE using the logMAR scale. The differences between before and after treatment were significant (P = ۰.۰۰۸ and P = ۰.۰۰۳, respectively). The mean macular thickness and CDR were unchanged. In those who referred after ۷۲ hours, BCVA was not changed significantly (۰.۹۶ ± ۰.۳ and ۰.۹۴ ± ۰.۲ vs. ۰.۹۷ ± ۰.۳ and ۰.۹۴ ± ۰.۲ in RE and LE respectively). Conclusion: Intravenous high dose methyl prednisolone may have benefits in the treatment of methanol optic neuropathy, if initiated before ۴۸ hours.

کلیدواژه ها

Methanol, Optic Neuropathy, Poisoning, Prednisolone

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.