Protective effects of zingerone against sodium arsenite-induced lung toxicity: A multi-biomarker approach
- سال انتشار: 1402
- محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 26، شماره: 9
- کد COI اختصاصی: JR_IJBMS-26-9_015
- زبان مقاله: انگلیسی
- تعداد مشاهده: 69
نویسندگان
Department of Physiology, Faculty of Medicine, Aksaray University, Aksaray, Türkiye
Department of Veterinary Biochemistry, Faculty of Veterinary, Atatürk University, Erzurum, Türkiye
Department of Veterinary Biochemistry, Faculty of Veterinary, Atatürk University, Erzurum, Türkiye
Department of Animal Science, Horasan Vocational College, Ataturk University, Erzurum, Türkiye
Department of Veterinary Biochemistry, Faculty of Veterinary, Kafkas University, Kars, Türkiye
Department of Medical Biochemistry, Faculty of Medicine, Aksaray University, Aksaray, Türkiye
چکیده
Objective(s): Sodium arsenite (SA) exposure is toxic to the body. Zingerone (ZNG) is a flavonoid with many biological properties found naturally in honey and plants. This study aimed to determine the effects of ZNG on SA-induced rat lung toxicity.Materials and Methods: Thirty-five male Sprague rats were divided into Control, SA, ZNG, SA+ZNG۲۵, and SA+ZNG۵۰ groups (n=۷). SA ۱۰ mg/kg and ZNG were administered at two doses (۲۵ and ۵۰ mg/kg) (orally, ۱۴ days). Analysis of oxidative stress, inflammation damage, apoptosis damage, and autophagic damage markers in lung tissue were determined by biochemical and histological methods. Results: The administration of ZNG reduced oxidative stress by increasing SA-induced decreased antioxidant enzyme activities, increasing Nrf-۲, HO-۱, and NQO۱, and decreasing MDA level. ZNG administration reduced inflammation marker levels. Anti-apoptotic Bcl-۲ increased and apoptotic Bax and Caspase-۳ decreased with ZNG. ZNG promoted the regression of autophagy by reducing Beclin-۱, LC۳A, and LC۳B levels.Conclusion: Evaluating all data showed that SA caused toxic damage to lung tissue by increasing inflammation, apoptosis, autophagy, and oxidant levels, whereas ZNG had a protective effect by reducing this damage.کلیدواژه ها
Apoptosis, Autophagy, Inflammation, Lung, Oxidative stress, Sodium arsenite, Toxicity, Zingeroneاطلاعات بیشتر در مورد COI
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