Effects of oleanolic acid administration on renal NF-κB/IL-۱۸/IL-۶ and YKL-۴۰/KIM-۱ pathways in experimental diabetic rats
- سال انتشار: 1402
- محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 26، شماره: 10
- کد COI اختصاصی: JR_IJBMS-26-10_009
- زبان مقاله: انگلیسی
- تعداد مشاهده: 171
نویسندگان
Artvin Coruh University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Artvin ۰۸۰۰۰, Turkey
Artvin Coruh University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Artvin ۰۸۰۰۰, Turkey
Department of Animal Nutrition and Nutritional Disorders, Faculty of Veterinary Medicine, Ataturk University, Erzurum ۲۵۲۴۰, Turkey
Department of Pathology, Faculty of Veterinary Medicine, Ataturk University, Erzurum ۲۵۲۴۰, Turkey
Department of Pathology, Faculty of Veterinary Medicine, Ataturk University, Erzurum ۲۵۲۴۰, Turkey
Department of Pathology, Faculty of Veterinary Medicine, Ataturk University, Erzurum ۲۵۲۴۰, Turkey
چکیده
Objective(s): Neuropathy, retinopathy, and nephropathy, known as the triopathy of diabetes, are the consequences of microvascular complications of diabetes. The present study aimed to investigate the potential protective effects of oleanolic acid (OA) administration against diabetic nephropathy considering biochemical and histopathological parameters.Materials and Methods: The rats with fasting blood glucose levels of ۲۰۰ mg/dl and above were considered diabetic after induction of diabetes via injecting STZ. The other half of the rats were not injected with STZ (healthy rats). Both healthy and diabetic rats were then divided randomly into two subgroups to be administered with either OA (۵ mg/kg) with ۱ ml tap water by oral gavage or ۱ ml tap water in the same route for ۲۱ days. Serum urea-N, Ca, P, and Mg as well as renal tissue MDA, SOD, NF-κB, IL-۶, IL-۱۸, AMPK, YKL-۴۰, and KIM-۱ levels were measured.Results: OA administration partially decreased levels of serum urea-N and P, as well as levels of renal tissue MDA and inflammation markers (NF-κB, IL-۶, IL-۱۸, YKL-۴۰, and KIM-۱) in the diabetic rats. It also partially increased serum Ca and renal tissue AMPK levels in diabetic rats. These positive effects were also seen in renal tissue histopathology.Conclusion: OA treatment partially alleviated renal damage inflammatory and oxidative profiles in diabetic rats.کلیدواژه ها
Cytokines, Diabetes, KIM-۱, Oleanolic acid, YKL-۴۰اطلاعات بیشتر در مورد COI
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