Ademola Famurewa - Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medical Sciences, Alex Ekwueme Federal University, Ndufu-Alike, Ikwo, Ebonyi State, Nigeria
Chima Ekeleme-Egedigwe - Department of Biochemistry, Faculty of Biological Sciences, Alex Ekwueme Federal University, Ndufu-Alike Ikwo, Abakaliki, Nigeria
Patience Ogbu - Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medical Sciences, Alex Ekwueme Federal University, Ndufu-Alike, Ikwo, Ebonyi State, Nigeria
Ayodeji Ajibare - Department of Physiology, Faculty of Basic Medical and Health Sciences, College of Medicine, Lead City University, Ibadan, Oyo State, Nigeria
Moshood Folawiyo - Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, Ekiti State University, Ado-Ekiti, Nigeria
Doris Obasi - Department of Biochemistry, Faculty of Biological Sciences, Alex Ekwueme Federal University, Ndufu-Alike Ikwo, Abakaliki, Nigeria
Arunaksharan Narayanankutty - Division of Cell and Molecular Biology, PG and Research Department of Zoology, St Joseph’s College (Autonomous), Devagiri, Kerala, India

Objective: Doxorubicin (DOX) is a frontline antineoplastic drug that kills cancer cells through genotoxic mechanism; however, it induces organ toxicities. This study assayed whether morin hydrate (MOH) could abrogate DOX hepatorenal toxicity in rats.Materials and Methods: There were ۴ groups of rats: Control, MOH, DOX and MOH + DOX. Rats were administered MOH (orally, ۱۰۰ mg/kg bw) for ۷ consecutive days, while DOX was injected (۴۰ mg/kg, ip) on the ۵th day only. Hepatorenal function markers, and glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) activities were estimated in both organs. Hepatorenal glutathione (GSH), malondialdehyde (MDA), and nitric oxide (NO) levels were estimated with histopathology.Results: DOX significantly (p<۰.۰۵) reduced antioxidant enzyme activities and GSH level, while NO and MDA levels increased (p<۰.۰۵) compared to the control. DOX prominently altered hepatorenal indices and induced histopathological alterations. MOH abrogated the DOX hepatorenal toxicity and alleviated the histological lesions in the liver and kidney.Conclusion: MOH restored the indices via antioxidant mechanism and downregulation of NO overproduction in rats.

Morin, Toxicity, Oxidative stress, chemotherapy, Anticancer drugs, Flavonoids