Possible Role of Oxidative Stress and Nrf۲/HO-۱ Pathway in Pentylenetetrazole-induced Epilepsy in Aged Rats
- سال انتشار: 1402
- محل انتشار: مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 12، شماره: 1
- کد COI اختصاصی: JR_RBMB-12-1_015
- زبان مقاله: انگلیسی
- تعداد مشاهده: 70
نویسندگان
Department of Medical Physiology, Faculty of Medicine, Mansoura University, Mansoura (۳۵۵۱۶), Egypt.
Department of Animal Husbandry and Development of animal wealth, Faculty of Veterinary Medicine, Mansoura University, Mansoura ۳۵۵۱۶, Egypt.
Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura ۳۵۵۱۶, Egypt.
Department of Medical Physiology, Faculty of Medicine, Mansoura University, Mansoura (۳۵۵۱۶), Egypt.
Department of Medical Physiology, Faculty of Medicine, Mansoura University, Mansoura (۳۵۵۱۶), Egypt.
Basic Science Department, Delta University for Science and Technology, Gamasa, Egypt.
Department of Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura, ۳۵۵۱۶, Egypt.
Department of Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura, ۳۵۵۱۶, Egypt.
Department of Medical Physiology, Faculty of Medicine, Mansoura University, Mansoura (۳۵۵۱۶), Egypt.
چکیده
Background: To examine the impact of aging on the response of rats to pentylenetetrazole (PTZ)-induction of epilepsy and the possible role of oxidative stress and nuclear factor erythroid ۲-related factor ۲ (Nrf۲)/ heme oxygenase (HO)-۱ pathway in this response. Methods: Forty male albino rats were equally allocated into ۴ groups; ۱) Young control (YC) group, aged ۸-۱۲ weeks, ۲) Old control (OC) group, aged ۲۴ months, ۳) PTZ-Young group: young rats received PTZ (۵۰ mg/Kg, i.p. every other day) for ۲ weeks and ۴) PTZ-Old group: as group ۳ but rats were old. The seizure score stage and latency to the first jerk were recorded in rats. Redox state markers in brain tissues including malondialdehyde (MDA), catalase and total antioxidant capacity (TAC) were evaluated. Also, the expression of Nrf۲ and HO-۱ genes were measured in the brain tissues. Results: Old rats showed an early and a significant rise in the seizure score with PTZ administration and a significant drop in the seizure latency compared to young rats (P < ۰.۰۱). Also, old rats showed a significantly higher MDA concentration and a significantly lower TAC and catalase activity than young rats (P < ۰.۰۱). Moreover, the expression of Nrf۲ and HO-۱ was significantly lowered in old rats compared to young rats with PTZ administration (P < ۰.۰۱). Conclusions: Aging increases the vulnerability of rats to PTZ-induced epilepsy. An effect might come down to the up-regulation of oxidative stress and the down regulation of antioxidant pathways including Nrf۲ and HO-۱.کلیدواژه ها
Aging, Epilepsy, HO-۱, Nrf۲, Oxidative stress, Pentylenetetrazole (PTZ).اطلاعات بیشتر در مورد COI
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