The Effects of Ultrasound, Infrasound, and Electroconvulsive Stimulations on Depression-like Behavior in Mice
- سال انتشار: 1399
- محل انتشار: مجله بین المللی علوم رفتاری، دوره: 14، شماره: 2
- کد COI اختصاصی: JR_BEHAVS-14-2_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 81
نویسندگان
Department of Psychology, Borujerd Branch, Islamic Azad University, Borujerd, Iran
Department of Psychology, Borujerd Branch, Islamic Azad University, Borujerd, Iran
Department of Psychiatry, Faculty of Medicine, Aja University of Medical Sciences, Tehran, Iran
Department of Psychology, Borujerd Branch, Islamic Azad University, Borujerd, Iran
چکیده
Abstract Introduction: In the present study, the effects of ultrasound, infrasound, and electroconvulsive stimulation on depression-like behavior was assessed in animal models. Method: For carrying out this study, ۶۰ male BALB/c mice (mean age of ۶۰ days, weight range of ۲۵ – ۳۰ g) were randomly selected. Depression was induced using reserpine ۰.۱ mg/kg i.p. for ۳۰ days. They were allocated to three groups of experimental (ultrasound, infrasound, and electroconvulsive stimulation) and one group of control animals, each including ۱۵ mice. Experimental animals received ultra- or infrasound ۰.۵ hours or ۱ electroconvulsive pulse, daily for ۱۰ days. Finally the Forced Swim Test was carried out. Results: There was a statistically significant difference between the groups regarding the duration of immobility posture [F(۳,۵۴) = ۹۹.۵۴, P = ۰.۰۰۱]. Mean immobility time was significantly longer in the control group compared to the other groups. Also, immobility was significantly longer for electroconvulsive compared to the ultra- and infrasound groups. Group ultrasound showed longer immobility than group infrasound; however, the difference was not significant. Conclusion: Ultrasound and infrasound stimulations are capable of decreasing depression-like behavior in mice. The results of this study were also compatible with the application of electroconvulsive therapy. However, a more successful response can be exploited with ultra- and infrasound stimulations.کلیدواژه ها
Keywords: Brain stimulation, depression, Electroconvulsive stimulation, Infrasound, Ultrasoundاطلاعات بیشتر در مورد COI
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