Roles of oxidative stress following HIV-infection
- سال انتشار: 1402
- محل انتشار: اولین همایش بین المللی زیست شناسی و علوم آزمایشگاهی
- کد COI اختصاصی: ZISTCONF01_032
- زبان مقاله: انگلیسی
- تعداد مشاهده: 155
نویسندگان
Student Committee of Clinical Virology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Department of Virology, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Department of Celullar and Molecular research, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
Department of ParaMedicine, Faculty of Medical Sciences, Islamic Azad University of Arak, Arak, Iran
Department of Microbiology, Faculty of Science, Site Imam Branch, Islamic Azad University, Zanjan, Iran
Student Committee of Clinical Virology Research Center, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Oxidative stress, characterized by an excess of reactive oxygen species (ROS), plays a significant role in many cellular processes and can lead to the damage of biological molecules and the alteration of their functions. This can result in a range of pathologies if ROS levels exceed the ability of the body's defense mechanisms to neutralize them. In this review, we discuss the markers of oxidative stress associated with HIV-۱ infection, the mechanisms by which the virus leads to high levels of ROS production, and the defense mechanisms of infected host cells. We also examine the limited data available on the impact of ROS on HIV-۱ replication and the role of redox alterations in HIV-۱ pathogenicity, including neurotoxicity and dementia, CD۴+/CD۸+ T-cell exhaustion, increased susceptibility to lung infections, and certainside effects of antiretroviral therapy. Additionally, we compare the pathologies caused by oxidative stress in HIV infection.کلیدواژه ها
Oxidative stress, HIV, ROS, neurologic disordersمقالات مرتبط جدید
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