The frequency of integrons of antibiotic resistant in Stenotrophomonas maltophilia isolates in Hamadan/Iran
- سال انتشار: 1395
- محل انتشار: فصلنامه میکروب شناسی پزشکی ایران، دوره: 10، شماره: 4
- کد COI اختصاصی: JR_IJMM-10-4_002
- زبان مقاله: انگلیسی
- تعداد مشاهده: 93
نویسندگان
Department of Microbiology,Hamadan University of Medical Sciences, Hamadan, Iran
Department of Microbiology,Hamadan University of Medical Sciences, Hamadan, Iran
Department of Microbiology,Hamadan University of Medical Sciences, Hamadan, Iran
Department of Microbiology,Hamadan University of Medical Sciences, Hamadan, Iran
Brucellosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
چکیده
Background and Aim: Stenotrophomonasmaltophilia is an important multidrug-resistant nosocomial pathogen that leads to respiratory tract infections and urinary tract. Due to the increasing of antibiotic resistance in S. maltophilia, treatment of infections caused by these bacteria has been difficult. The aims of this study was detection of antibiotic resistance pattern and identify of class I and II integrons and associated gene cassettes in clinical isolates of S. maltophilia. Materials and Methods: In this cross-sectional study, of ۲۴۶ clinical specimen were collected from educational hospitals of Hamadan university of medical sciences, ۱۲ isolates of S. maltophilia were collected in ۲۰۱۵. After the culture, isolates were verified by standard biochemical methods. Antibiotic susceptibility was determined against ۱۳ antibiotics. Presence of Class I and II integrons genes were tested using specific primers by PCR. Results: In the pattern of antibiotic resistance, the highest resistance rate showed to Cefditoren, Ceftriaxone, Cefotaxime antibiotics and the lowest resistance to Amikacin, Imipenem, Ofloxacin, Trimethoprim-Sulphamethoxazole and Ciprofloxacin antibiotics were reported. All S. maltophilia strains carried class I integrons. No isolate carry class II integrons and gene cassettes. Conclusions: The result of this study indicates a high prevalence of class I integrons in S.maltophilia isolates. Thus, identification of these resistance genes for infection control programs and to prevent the spread of resistant strains is very important.کلیدواژه ها
Stenotrophomonas maltophilia isolates, Integron, Antibiotic resistance, استنوتروفورموناس مالتوفیلا, اینتگرون, مقاومت آنتی بیوتیکیاطلاعات بیشتر در مورد COI
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