The effect of Zinc on the Immune responses of pneumococcal vaccination in elderly
- سال انتشار: 1395
- محل انتشار: فصلنامه میکروب شناسی پزشکی ایران، دوره: 10، شماره: 5
- کد COI اختصاصی: JR_IJMM-10-5_009
- زبان مقاله: انگلیسی
- تعداد مشاهده: 202
نویسندگان
Department of of Infection disease, Kermanshah University of Medical Sciences, Kermanshah, Iran
Department of of Infection disease, Kermanshah University of Medical Sciences, Kermanshah, Iran
Department of of Infection disease, Kermanshah University of Medical Sciences, Kermanshah, Iran
Department of of Infection disease, Kermanshah University of Medical Sciences, Kermanshah, Iran
Department of Biostatistics and Epidemiology, School of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran
Department of of Infection disease, Kermanshah University of Medical Sciences, Kermanshah, Iran
Department of Medical Microbiology, School of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran
Department of of Infection disease, Kermanshah University of Medical Sciences, Kermanshah, Iran
چکیده
Background and Aim: Considering the zinc sulfate as an immunumedolator in antibody production, the aim of this study was to investigate the effect of zinc sulfate on the immunological response of pneumococcal vaccines in elderly people over ۶۵. Materials and Methods: In this case-control study in ۲۰۱۲, ۱۲۰ patients (over ۶۵ years old) were selected and randomly divided into two separate equal study and control groups. Pneumococcal vaccine injected with the dose of ۲۳ ppv to study and control group then zinc sulfate supplement capsule taken by the study group and a sugar capsule as a placebo by control group for one month period as well. Blood samples were taken before and one month after vaccination, specific antibody (Ab) level against pneumococcal polysaccharide capsule, was measured with Maxisorb ELISA kit. Then findings interpreted with Stata software version ۸ (sas ver ۸, USA), a t-test was done for assessment of the relationship between independent variables. The effect of zinc, age, smoking and BMI has been assessed on the level of Ab production with regression interpreter. Results and Conclusions: The average increase in antibody levels before and one month after vaccination in the control group, ۴۲.۸۷ ± ۲۵.۲۱ to ۱۱۸.۸۷ ± ۲۹ and in the study group were from ۴۱.۷۶ ± ۲۷.۵۱ to ۱۱۷.۶۶ ± ۳۲.۵۳ units per mL. Zinc, age, sex, BMI and smoking with ۹۵% reliability had no effect on antibody production in both groups. subscription of zinc sulfate for one month period as an immunomodulator after pneumococcal vaccination has no significant effect on the level of antibody production in response to pneumococcal ۲۳ valent vaccines.کلیدواژه ها
Vaccination, Pneumococci, Zinc, Antibody, واکسیناسیون, پنوموکوک, روی(zinc), آنتی بادیاطلاعات بیشتر در مورد COI
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