Assessment of Alpha-۱ Antitrypsin Deficiency in Patients with Severe Chronic Obstructive Pulmonary Disease

سال انتشار: 1394
محل انتشار: مجله بین المللی آزمایشگاه پزشکی، دوره: 2، شماره: 2
کد COI اختصاصی: JR_JIML-2-2_005
زبان مقاله: انگلیسی
تعداد مشاهده: 66

نویسندگان

Internal Medicine Department, Research Centre for Tropical and Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran.

Hossein Ali Khazaei

Immunology and Hematology Department, Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.

Vida Pejman

Zahedan University of Medical Sciences, Zahedan, Iran.

چکیده

Background and Aims: Chronic obstructive pulmonary disease (COPD) is a kind of pulmonary diseases characterized by chronic obstruction of lung that is in the form of a diffuse narrowing of airways resulting in air flow resistance. Alpha-۱ antitrypsin (AAT) deficiency is genetically relatively common risk factor in patients with COPD throughout the world and the exact cause of its prevalence is unknown. We therefore performed a study to determine the frequency of AAT deficiency in patients with severe COPD compared to the healthy controls. Materials and Methods: In this cross-sectional case control study, AAT serum level in ۶۰ patients with severe COPD for whom the history and spirometry test with FEV۱< ۵۰% had been confirmed based on gold criteria as well as ۶۰ healthy controls, were tested using commercial kit and nephelometry method. Results: The lowest serum levels of AAT measured in patients was < ۰.۳۴۹ g/l and the highest was ۳.۰۹۹ g/l. These were obtained in healthy subjects as ۱.۱۸۰ g/l and ۴.۱۹۵ g/l respectively. Out of ۶۰ patients, ۴ (۶.۷%) had partial deficiency of AAT (AAT< ۱ g/l) and ۶ (۱۰%) had definite shortage of AAT (AAT< ۰.۵ g/l). In healthy subjects, we did not find any definite and relative lack of AAT. The comparison of results obtained from these two groups indicated a significant difference between frequency of AAT (P=۰.۰۰۱). Conclusions: Our findings revealed the frequency of AAT deficiency, as a factor involved in COPD disease, to be ۱۰% and can be the reason for the high prevalence and severity of COPD in Zahedan city.

کلیدواژه ها

Alph-۱-antitrypsin, COPD, Zahedan

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