Effect of resistance training on FTO and PPAR-y genes expression in muscle tissue of obese diabetic rats.
- سال انتشار: 1401
- محل انتشار: مجله رهیافت های نو در فیزیولوژی ورزشی، دوره: 4، شماره: 7
- کد COI اختصاصی: JR_NASS-4-7_012
- زبان مقاله: انگلیسی
- تعداد مشاهده: 206
نویسندگان
Wellness and lifestyle science initiative group, Ph.D. student of kinesiology and health, school of art and science, Rutgers University New Brunswick, New Brunswick, New Jersey, United States
M.Sc Student of Exercise Physiology, Department of Exercise Physiology, Islamic Azad University, Tehran North Branch, Tehran, Iran
Ph.D. student of Sports Sciences, Faculty of Sports Sciences, University of Coimbra, Portugal
Allameh Bohlool Gonabadi Hospital, Gonabad University of Medical Sciences, Gonabad, Iran
چکیده
Purpose: It has been well proven that type ۲ diabetes is one of the most common non-communicable diseases leading to many complications and mortality every year. The aim of this study was to investigate the effect of resistance training on FTO and PPAR-y gene expression in muscle tissue of obese diabetic rats. Study design: This experimental study was performed on ۱۲ male Wistar rats (۱۰ weeks old and ۲۲۰±۲۰ g bodyweight). Methods: Animals received ۶ weeks high-fat diet and then in order to induce type ۲ diabetes an intraperitoneal injection of a single dose of ۳۰ mg/kg freshly prepared streptozotocin (STZ) (Sigma, USA) solved in citrate buffer (pH ۴.۵) was performed. Diabetic rats were divided into two (Resistance and control) groups randomly. The resistance program included ۶ weeks, ۵ sessions per week. The muscle expression of FTO and PPAR-γ was measured using the real-time PCR method. Independent t-test and Analysis of covariance (ANCOVA) were applied to compare the means. Results: The muscle mRNA expression of PPAR-γ and body weight significantly increased after ۶ weeks of resistance training (p=۰.۰۳۱, p=۰.۰۳۷; respectively) but there was no significant change in the muscle mRNA expression of FTO (p=۰.۳۱۷). Also, blood glucose significantly decreased in the training group compared to the control group (p=۰.۰۱). Conclusion: According to the results of this study, it can be noted that ۶-week resistance training by decreasing glucose levels and increases insulin sensitivity, and the muscle expression of PPAR-γ plays a prominent role in the control and treatment of type ۲ diabetes in obese patients.کلیدواژه ها
exercise, Metabolic diseases, Gene expression, Diabetics, resistance trainingاطلاعات بیشتر در مورد COI
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