Thromboembolic Manifestations in Hospitalized COVID-۱۹ Patients in India- A Single-Centre Retrospective Study
- سال انتشار: 1401
- محل انتشار: فصلنامه عفونت، اپیدمیولوژی و پزشکی، دوره: 9، شماره: 1
- کد COI اختصاصی: JR_IEM-9-1_009
- زبان مقاله: انگلیسی
- تعداد مشاهده: 156
نویسندگان
Assistant Professor, Department of Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, India
Assistant Professor, Department of Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, India
Assistant Professor, Department of Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, India
Associate Professor, Department of Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, India
Professor, Department of Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, India
چکیده
Backgrounds: This study aimed to evaluate the incidence and clinical profile of thromboembolic disease in COVID-۱۹ patients and analyze its association with D-dimer and Interleukin (IL)-۶ levels. Materials & Methods: This was a retrospective, single-center study conducted by analyzing data obtained from the case records of COVID-۱۹ confirmed patients with thromboembolic manifestations in India during January ۲۰۲۰ to February ۲۰۲۲. Patients with conditions such as malignancy, prothrombotic states, and autoimmune diseases were excluded from the analysis. D-dimer and IL-۶ levels and thrombotic events were analyzed along with comorbid conditions like diabetes mellitus (DM), hypertension, and dyslipidemia. Chi-square tests were used to evaluate the association of various thrombotic manifestations with D-dimer and IL-۶ levels. A p-value of ≤ .۰۵ was considered statistically significant. Findings: The mean age of ۸۸ COVID-۱۹ confirmed cases with thrombotic manifestations was ۶۱.۰۱±۱۵.۲۳ years, and the majority (۶۲.۵%) of the cases were male. D-dimer and IL-۶ levels were elevated in ۷۸.۴۱ and ۸۰.۶۸% of the cases, respectively. The predominant thrombotic manifestation was pulmonary thromboembolism (PTE) (۴۸.۸۶%), followed by acute coronary syndrome (ACS) (۳۶.۳۶%), cerebrovascular accident (CVA) (۲۲.۷۳%), etc. There was no significant association between various thrombotic manifestations and D-dimer and IL-۶ levels. Conclusion: PTE was the predominant thromboembolic manifestation in COVID-۱۹ patients in the current cohort. Elevated D-dimer and IL-۶ levels though found in the majority of the patients were not associated with thrombotic events. However, early recognition and treatment could reduce morbidity in COVID-۱۹ patients.کلیدواژه ها
COVID-۱۹, Thromboembolism, Pulmonary embolism, D-dimer, Interleukin-۶اطلاعات بیشتر در مورد COI
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