Radioprotective Effects of Melatonin on Gamma Radiation- Induced Tissue Damage in Rats
- سال انتشار: 1402
- محل انتشار: مجله علوم پیشرفته زیست پزشکی، دوره: 13، شماره: 2
- کد COI اختصاصی: JR_JABS-13-2_003
- زبان مقاله: انگلیسی
- تعداد مشاهده: 196
نویسندگان
Department of Nutrition, School of Health, Zabol University of Medical Sciences, Zabol, Iran
Department of Basic Sciences, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
Department of Medical Physics, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
Department of Pathology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
Department of Clinical Psychology, Faculty of Humanities, Sirjan Branch, Islamic Azad University, Sirjan, Iran
Clinical Immunology Research Center, Zahedan University of medical sciences, Zahedan, Iran
Department of Immunology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
چکیده
Background & Objective: Gamma rays are widely used in medicine despite their harmful effects on health. Our study evaluated the protective effects of melatonin on kidney, heart, and liver tissues. Materials & Methods: Seventy-two adult male Wistar rats were categorized into nine groups. Groups ۲ and ۳ only received whole-body γ-ray irradiation (WBI) (۲.۰ Gy), no melatonin, interval time (IT) ۸hr and ۲۴hr. Groups ۴ and ۵ received WBI (۸.۰ Gy, no melatonin, ۸hr and ۲۴hr). Groups ۶ and ۷ received melatonin at ۶۰ minutes (min) before WBI(۲.۰ Gy). Groups ۸ and ۹ received melatonin before WBI(۸.۰ Gy). All the rats were sacrificed ۸ or ۲۴ h after the experiments for laboratory and histopathological analysis. Serum levels of Blood Urea Nitrogen(BUN), Creatinine (Cr), Lactate dehydrogenase (LDH), Potassium (K), Gamma-glutamyl Transferase (GGT), Serum Glutamic-Oxaloacetic Transaminase(SGOT), Serum Glutamic-Pyruvic Transaminase(SGPT), Alkaline Phosphatase(ALP), c-reactive protein(CRP), Troponine(TPO) and histological features of liver, heart and kidney tissues were assessed. Statistical analysis was performed by One-Way ANOVA. Results: Our data did not indicate significant differences in BUN, Cr, K, and CRP between groups with or without melatonin treatment (P> ۰.۰۵); but differences were significant for LDH, GGT, SGOT, SGPT, ALP, and TPO (P< ۰.۰۵). The results showed that radiation-induced histopathological effects on the liver, heart, and kidneys were mitigated in the groups six to nine. Conclusion: The existence of significant differences in serum levels of LDH, GGT, SGOT, SGPT, ALP, and TPO in groups(۶ to ۹) and amelioration of the histopathological effects of irradiation on the liver, heart, and kidneys in the groups six to nine showed that the melatonin(۱۰۰ mg/kg) is able to protect the body in gamma-radiation(۲.۰ Gy and ۸.۰ Gy).کلیدواژه ها
Melatonin, Oxidative stress, Whole-Body Irradiation, Histology.اطلاعات بیشتر در مورد COI
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