Antimicrobial Activity and Wound Healing Properties of Aloe Arborescens Extract: An in Vivo Study
- سال انتشار: 1402
- محل انتشار: مجله علوم پیشرفته زیست پزشکی، دوره: 13، شماره: 2
- کد COI اختصاصی: JR_JABS-13-2_006
- زبان مقاله: انگلیسی
- تعداد مشاهده: 314
نویسندگان
Department of Chemistry, Darab branch, Islamic Azad University, Darab, Iran
Department of Chemistry, Fasa branch, Islamic Azad University, Fasa
Department of Chemistry, Darab branch, Islamic Azad University, Darab, Iran
Department of Pathology, Faculty of Veterinary Medicine, Kazerun Branch, Islamic Azad University, Kazerun, Iran
Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
Department of Microbiology, Faculty of Veterinary Medicine, Kazerun Branch, Islamic Azad University, Kazerun, Iran
Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
Department of Clinical Biochemistry, Fasa University of Medical Sciences, Fasa, Iran
Noncommunicable Diseases Research Center, Fasa University of MEdical Sciences, Fasa, Iran
چکیده
Background & Objective: Burn is one of the prominent causes of death around the world, however drug discovery attempts for burn healing has not been entirely successful. Aloe arborescens (A. arborescens), is effective in the burning wounds healing and growth inhibition of bacterial pathogens. Our objective was to assess the wound healing and antibacterial effects of A. arborescens in vivo. Materials & Methods: Thirty healthy Wistar rat animals were enrolled. The treatment process continued for ۲۱ days and sampling was conducted on days ۱۴ and ۲۱ and the tissue slides were sent to the pathology laboratory for testing. The bactericidal activity of A. arborescens extract was evaluated using the disc diffusion method. Results: A. arborescens demonstrated a significant effect on the healing of burn wounds. Furthermore, the antibacterial effects of the A. arborescens extract against Gram-negative (Escherichia coli, Pseudomonas aeruginosa) was significantly higher than that against Gram-positive (Staphylococcus aureus, Bacillus cereus) bacterial species. Conclusion: In conclusion, this study indicated that A. arborescens extract had an improving effect on the healing process of third degree burns without toxicity to the tissue.کلیدواژه ها
Wound healing, Burns, Herbal Medicines, Aloe Arborescens, in vivoاطلاعات بیشتر در مورد COI
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