Yasaman Sanaei - Department of Applied Chemistry, Faculty of Science, South Tehran Branch, Islamic Azad University, Tehran, Iran.
Mohsen Zeeb - Department of Applied Chemistry, Faculty of Science, South Tehran Branch, Islamic Azad University, Tehran, Iran.

Carbonized cotton Fabric (CCF) was fabricated as sorbent for magnetic solid phase extraction (SPE) of drug in human plasma, which was combined with high performance liquid chromatography ultraviolent detection (HPLC–UV). The Carbonized cotton Fabric was syntesised by using cotton fabric and modified by Fe۳O۴ because of its extremely high magnetic properties and allow the sorbent to be easily divided from the sample solution by using an external magnet. Sorbent characterization was carried out utilizing X-ray diffraction (XRD), Fourier transform-infrared (FT-IR) spectroscopy and Field-emission scanning electron microscopy (FE-SEM). Important analytical parameters such as pH, amount of sorbent, desorption condition and ultrasonic bath time that effect the developed magnetic solid phase extraction method were investigated and optimum parameters were detected. Carbonized cotton Fabric / Fe۳O۴ was used as sorbent for the determination and preconcentration of drug in human plasma and some pharmacokinetic data were comprehensively examined.

Carbonized cotton fabric, Fe۳O۴, Magnetic solid phase extraction, High-performance liquid chromatography