fect of the Interaction between HAS and Deltamethrin in the Presence of SilverNanoparticle by Fluorescence Spectroscopic

Protein is an important chemical substance in our life and the major target of many types of medicine in the body. So far, there have been many examples in studying the molecular interactions of different kinds of drugs with various cellular proteins. However, reports on the interaction of effective chemical compound present in Chinese herbal medicine with cellular protein are still scarce. Serum albumin, the most abundant protein in the blood circulatory system, plays an important role in the transport and deposition of a variety of endogenous and exogenous substances such as fatty acids, hormones, and drugs. It has been one of the most extensively stud-ied proteins. Human serum albumin (HSA) is the most important and abundant constituent of blood plasma. Recently, the three-dimensional structure of HSA was determined through X-ray crystallographic measurement. Organophosphate poisoning has significant gastrointestinal manifestations including vomiting, diarrhea, cramps and increased salivation. We report an uncommon gastrointestinal complication of multiple small intestinal perforations following organophosphorus poisoning. Deltamethrin ۲.۵% EC insecticide is the first non-systemic pyrethroid compound whose insecticidal power is higher than other poisons of this group. This substance has contact and digestive effects on most insects. Deltamethrin has a knock-down effect and causes the insect to paralyze and fall quickly. The insecticidal effect of Deltamethrin depends on the recommended dose for each pest and the complete coverage of the poison layer on the surface of the leaf. and winter and spring wheat, cabbage seed weevil in spring and winter canola, stem weevil in spring and winter canola, leaf eaters in ornamental plants, greenhouse vegetables and green space, seed and stone fruit trees, apple worm in apple trees and so on. is used Nano particulate delivery systems are extensively investigated as a drug delivery strategy in the pharmaceutical research. In general, nano carri-ers may protect a drug from degradation, enhance drug absorption by facilitating diffusion through epitheli-um, modify pharma cokinetic and drug tissue distribution profile and/or improve intracellular penetration and distribution. Furthermore, by modulating the surface properties, composition and milieu, the desired release pattern of the drug and its biodistribution can be achieved. This study is only an idea and no tests have been done on it The results of this article can be used to find ways to reduce the free concentration of Deltamethrin in the bloodا:

کلیدواژه ها:

Human Serum Albumin (HSA) Protein ، Deltamethrin Silver Nonoparticles ، Fluorescence Spectroscopy.