Effect of eight weeks of swimming training and CBD oil consumption on PI۳K and ERK gene expression in the heart tissue of rats with myocardial infarction

  • سال انتشار: 1401
  • محل انتشار: مجله دانشگاه علوم پزشکی شهرکرد، دوره: 24، شماره: 2
  • کد COI اختصاصی: JR_SKUMS-24-2_002
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 69
دانلود فایل این مقاله

نویسندگان

Mostafa Safian Boldaji

Department of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran

Khosro Jalali Dehkordi

Department of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran

Farzaneh Taghian

Department of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran

چکیده

Background and aims: Cannabidiol (CBD) oil consumption can positively contribute to controlling the cardiovascular risk factors. Exercise can also be effective in rehabilitating myocardial infarction by strengthening muscle tissue. This study, therefore, aimed to evaluate the effect of eight weeks of swimming training together with CBD oil consumption on PI۳K and ERK gene expression in the heart tissue of rats with myocardial infarction. Methods: In this experimental trial, ۲۵ ovariectomized rats with myocardial infarction were divided into five groups, including ۱) control, ۲) MI ۳) MI +training, ۴) MI + supplement, and ۵) MI +training+ supplement groups. Myocardial ischemia was induced by subcutaneous injection of isoproterenol (۵۰ mg/kg intravenously) in myocardial infarction rats. Groups ۳ and ۴ received ۵۰ mg/kg CBD as gavage on a daily basis for eight weeks, and groups ۲ and ۴ performed swimming training five days a week. One-way analysis of variance (ANOVA) with Tukey’s post hoc test was performed to analyze the findings (P < ۰.۰۵). Results: Induction of myocardial infarction contributed significantly to reducing PI۳k and ERK gene expression in the heart tissue (P = ۰.۰۰۱). However, swimming training with CBD oil consumption contributed significantly to increasing PI۳K (P = ۰.۰۰۳) and ERK (P = ۰.۰۰۱) gene expression in the heart tissue of rats with myocardial infarction. Conclusion: Seemingly, swimming training along with CBD oil consumption had more favorable effects on improvement of PI۳K and ERK gene expression levels in myocardial infarction than either alone. Therefore, it was recommended that CBD oil together with swimming training should be employed when dealing with myocardial infarction.

کلیدواژه ها

Swimming training, CBD oil, PI۳K, ERK, Myocardial infarction

مقالات مرتبط جدید

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.