MicroRNA۱۵۵ May Be an Important Part of Human Papilloma Virus-Related Cancers
عنوان مقاله: MicroRNA۱۵۵ May Be an Important Part of Human Papilloma Virus-Related Cancers
شناسه ملی مقاله: JR_JCMI-9-2_006
منتشر شده در در سال 1401
شناسه ملی مقاله: JR_JCMI-9-2_006
منتشر شده در در سال 1401
مشخصات نویسندگان مقاله:
Banafsheh Douzandeh-Mobarrez - Department of Microbiology, Kerman Branch, Islamic Azad University, Kerman, Iran
Ashraf Kariminik - Department of Microbiology, Kerman Branch, Islamic Azad University, Kerman, Iran
Babak Kheirkhah - Department of Veterinary Medicine, Baft Branch, Islamic Azad University, Baft, Iran
خلاصه مقاله:
Banafsheh Douzandeh-Mobarrez - Department of Microbiology, Kerman Branch, Islamic Azad University, Kerman, Iran
Ashraf Kariminik - Department of Microbiology, Kerman Branch, Islamic Azad University, Kerman, Iran
Babak Kheirkhah - Department of Veterinary Medicine, Baft Branch, Islamic Azad University, Baft, Iran
Background: Micro-RNAs (miRs) play several roles during infections with viruses. Therefore, the roles of
miR۲۱ and mir۱۵۵ in the induction of the viral-related cancers have been the focus of attention in several
studies. High risk human papilloma viruses (HPVs) are the main factors negatively contributing to the
induction of HPV-related cancers. This study aimed to evaluate the expression of miR۲۱ and mir۱۵۵ in the
patients with HPV-high risk genotypes in order to explore the roles of the miRs in the induction of HPVrelated
cancers.
Methods: In this study, ۴۰ women infected with the high-risk HPV genotypes as well as ۴۰ healthy controls
were examined regarding the relative expression of miR۲۱ and mir۱۵۵ by adopting real-time polymerase
chain reaction (PCR) technique. U۶ was used for data normalization of miRNAs.
Results: Relative expressions of both miR۲۱ and miR۱۵۵ were significantly higher in the HPV-infected
patients compared to those in non-infected women.
Conclusions: It was concluded that miR۲۱ and miR۱۵۵ may have played key roles in the induction of HPVrelated
cancers among Iranian patients.
کلمات کلیدی: Human papilloma virus, MicroRNA, Cervical cancer
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1700774/