Evaluation of Tissue Changes in the Hearts of Rats Infected with Toxoplasma Gondi
- سال انتشار: 1399
- محل انتشار: مجله بین المللی انگل شناسی پزشکی و علوم اپیدمیولوژی، دوره: 1، شماره: 2
- کد COI اختصاصی: JR_IJMPES-1-2_007
- زبان مقاله: انگلیسی
- تعداد مشاهده: 66
نویسندگان
Faculty of Veterinary Medicine, Tabriz branch, Islamic Azad University, Tabriz, Iran
Department of Pathobiology, Tabriz Branch, Islamic Azad University, Tabriz, Iran
Departement of Parasitology, Tabriz Branch, Islamic Azad University, Tabriz, Iran
چکیده
Introduction: Toxoplasma gondii is a protozoan parasite that is globally widespread and infects humans and animals. Obligate intracellular parasites enter many organs and tissues through the bloodstream, where they invade and proliferate into cells, eventually destroying them. The aim of this study was to evaluate the extent of cardiac tissue changes in rats infected with T. gondii. Methods: Male Wistar rats (n=۳۰) were allocated to three groups as follows: control group (n=۱۰), T۱ group that received ۰.۳ mL of T. gondii tachyzoite (IP) (n=۱۰), and T۲ group that received ۰.۶ mL of T. gondii tachyzoite (IP) (n=۱۰). However, the control group just received an equal volume of distilled water daily (IP). Animals were kept in standard condition. Forty days after inducing toxoplasmosis, heart tissues of rat in all groups were removed and prepared for histopathological examinations of heart tissue under optical microscopy after hematoxylin and eosin staining and calculation of heart tissue weight. Results: Heart tissue weight significantly decreased in groups that received ۰.۳ and ۰.۶ mL of T. gondii tachyzoite in comparison to control groups. In histopathological studies of heart tissue under optical microscopy, atrophy and necrosis were observed in heart tissues in T. gondii groups. Conclusion: Since this parasite caused necrosis of heart cells in rats in our study, it is suggested that in preventing T. gondii infection, health measures should be taken to promote human and animal health.کلیدواژه ها
Heart tissue, Toxoplasma gondii, Rat, Tissue changesمقالات مرتبط جدید
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