Mohsen Arabi - Preventive Medicine and Public Health Research Center, Family Medicine Department, Iran University of Medical Sciences, Tehran, Iran
Raheleh Alimoradzadeh - Firoozabadi Clinical Research Development Unit (FACRDU), University of Medical Sciences (IUMS), Tehran, Iran
Alireza Makian - Firoozabadi Clinical Research Development Unit (FACRDU), University of Medical Sciences (IUMS), Tehran, Iran
Seyed Javad Shariat Nabavi - Isfahan AL-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Nonalcoholic fatty liver disease (NAFLD) refers to fat accumulation in hepatic cells due to alcohol consumption, hepatitis, and drugs. The prevalence of this disease has been reported at ۲۰-۵۰% in western and۱۲ - ۱۳% in Latin countries. Patientswhosuffer from obesity, diabetes, and insulin resistance may be affected more than others. This disease is symptomless, and its paraclinical diagnosis is achievable by increasing the hepatic enzymes. Ultrasonography and fibroscan are some of thecommondiagnostic methods for this disease. The first treatment for this disease is weight loss and physical activities. Vitamin E can improve histopathological changes in terms of medications. While pioglitazone is an effective blood sugar-lowering drug, metformin has no role in treating diabetes or prediabetes.

Nonalcoholic Fatty Liver, NAFLD, Nonalcoholic Steatohepatitis, NASH, Diagnosis, Treatment, Guideline