Relationship between DNA methylation mechanism and Sonic Hedgehog family (SSH) genes in carcinogenesis and tumorigenesis of gastrointestinal cancers
محل انتشار: مجله سرطان شناسی و علوم پزشکی، دوره: 2، شماره: 2
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 89
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شناسه ملی سند علمی:
JR_JCOMS-2-2_007
تاریخ نمایه سازی: 28 تیر 1402
چکیده مقاله:
Gastrointestinal cancers are among the most serious cancers. In addition to environmental factors, genetic and
epigenetic factors also play a key role in the development of gastrointestinal cancers. Since many molecular
pathways are involved in the development of this type of cancer, the study of the function of molecular mechanisms
involved in carcinogenesis and tumorigenesis and their relationship with genes involved in this malignancy in
different molecular pathways to identify biomarkers used in early detection it is of great importance. The role of the
Sonic Hedgehog signaling pathway in maintaining and controlling stem cell growth and its association with genes
involved in gastrointesti nal cancers has been reported. In this study, the importance and relationship between the
DNA methylation mechanism and genes of the Sonic Hedgehog family in carcinogenesis and tumorigenesis of
gastrointestinal cancers will be investigated.
کلیدواژه ها:
نویسندگان
Sogand Vahidi
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Fatemeh Nejatifar
Department of Hematology and Oncology, Razi hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Seyedeh Elham Norollahi
Cancer Research Center and Department of Immunology, Semnan University of Medical Sciences, Semnan, Iran
Ali Akbar Samadani
Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran- Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran