Antianaemic property of Ficus capensis leaves and its combination with Cnidoscolus aconitifolius leaves in phenylhydrazine-induced anemic rats
- سال انتشار: 1400
- محل انتشار: Journal of Herbmed Pharmacology، دوره: 11، شماره: 4
- کد COI اختصاصی: JR_HERM-11-4_007
- زبان مقاله: انگلیسی
- تعداد مشاهده: 56
نویسندگان
Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria
Department of Chemistry, Biochemistry and Molecular Biology, Faculty of Science, Alex Ekwueme Federal University, Ndufu-Alike Ikwo, Ebonyi State, Nigeria
Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria
Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria
چکیده
Introduction: Anemia is a common health condition caused by a decrease in red blood cells. Some medicinal plants are used as a remedy to treat anemia. This study compares the anti-anemic properties of different doses of the aqueous extracts of Ficus capensis (AEFC) and its combination with the aqueous extract of Cnidoscolus aconitifolius (AECA) in phenylhydrazine-induced anemic rats. Methods: Anemia was induced by intraperitoneal injection of ۲۰ mg/kg phenylhydrazine for five consecutive days. Graded doses of the extracts were given by oral gavage once a day continuously for ۳۰ days. At the end of the treatment, blood was collected for hematological analysis. Results: The antianemic effects of AEFC and its combination with AECA were demonstrated by significant increases (P < ۰.۰۵) in the hemoglobin (HGB), packed cell volume (PCV) and red blood cell (RBC) count of the extract-treated groups compared to the anemic control group. There was a better increase in the HGB levels of a combination of ۴۰۰ mg/kg AEFC + AECA (۱۳.۹۷ ± ۲.۵۳) compared to ۴۰۰ mg/kg AEFC (۱۲.۰۶ ± ۰.۰۲). The PCV increased more in ۴۰۰ mg/kg combination of AEFC + AECA (۴۱.۹۴ ± ۰.۳۷) compared to ۴۰۰ mg/kg AEFC (۳۶.۳۱ ± ۱.۵۱). A significant (P < ۰.۰۵) increase was observed in the RBC count of a combination of ۴۰۰ mg/kg AEFC + AECA (۶.۳۶±۰.۵۱) compared to ۴۰۰ mg/kg AEFC (۴.۷۵ ± ۰.۴۶). Conclusion: Although AEFC improved the haematological parameters of the animals when administered alone, its combination with AECA yielded a far much better result by totally restoring the haematological parameters of the phenylhydrazine-induced anemic rats to normal.کلیدواژه ها
Anemia, Aqueous extract, Hemoglobin, Packed cell volume, Red blood cellsمقالات مرتبط جدید
- Phenolic fraction concentrates supplementation ameliorates learning and memory impairments in chronically stressed streptozotocin-diabetic rats by reducing brain tumor necrosis factor-α
- Chemical composition of Prangos ferulacea (L.) Lindl., and Prangos uloptera DC. essential oils and their antifungal activities
- Effect of ethyl acetate fraction of Costus afer on glycaemic control and essential haematological and biochemical indices of streptozotocin-induced diabetic rats
- Insulin supplemented with phenolic fraction concentrates displays anxiolytic and antidepressant-like properties with reductions of oxidative brain damage in chronically stressed diabetic rats
- Evaluation of erythrocyte viability, antioxidant capacity and antiplasmodial activity induced by alkaloid extract of Phyllanthus amarus
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.