Can Viral Load Predict Liver Histology in Patients With Chronic Hepatitis B?

  • سال انتشار: 1394
  • محل انتشار: مجله پزشکی سفر و بهداشت جهانی، دوره: 3، شماره: 1
  • کد COI اختصاصی: JR_IJTMGH-3-1_005
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 63
دانلود فایل این مقاله

نویسندگان

Ashraf Karbasi

Baqiyatallah Research Center of Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran

Behzad Bafandeh

Baqiyatallah Research Center of Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran

Seyed-Moayed Alavian

Baqiyatallah Research Center of Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran

Amin Saburi

Chemical Injury Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

چکیده

Introduction: Hepatitis B virus (HBV) infection is a global public health problem. Serum HBV DNA measurement is a non-invasive test that predicts the liver disease progression. The aim of this study was to determine the HBV DNA level and look for a relation between the HBV DNA level and liver histology. Methods: This was a cross sectional study on chronic hepatitis B infected patients in Tehran Hepatitis Center from ۲۰۰۶ to ۲۰۱۰. Percutaneus liver biopsy was performed in all patients. Patients with a history of any treatment and co-infection of HCV, HDV and HIV were excluded. Results: ۳۰۱ patients were included in this study. The mean age was ۳۴.۶۳±۱۳.۲۵ years. Mean serum HBV DNA level was ۱.۳۵* ۱۰۸ ± ۱۰.۵*۱۰۹ copies/ml.  Mean inflammatory score (grade) was ۵.۵۴±۳.۲۶ and fibrosis (stage) was ۱.۹۳±۱.۵۶. There wasn’t any significant relation between age and sex with liver histology. No significant relation was seen between liver histology and the HBV DNA level. HBe Ag positive patients had a higher serum HBV DNA level. Conclusion: There wasn’t any significant relation between liver histology and the HBV DNA level. We suggest using liver biopsy as a golden standard. In addition we need more studies in this field.

کلیدواژه ها

Chronic hepatitis B, Liver Histology, Serum HBV DNA

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.