Investigating the Risk Factors of Hypoparathyroidism after Total Thyroidectomy
- سال انتشار: 1402
- محل انتشار: مجله اوراسیا تحقیقات در شیمی، پزشکی و نفت، دوره: 2، شماره: 2
- کد COI اختصاصی: JR_EJCMPR-2-2_008
- زبان مقاله: انگلیسی
- تعداد مشاهده: 80
نویسندگان
Assistant Professor of Surgery, Department of General Surgery, Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
۲. Assistant Professor of Thoracic Surgery, Department of Cardiovascular Surgery, Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
چکیده
Introduction: The aim of this study was to determine the outcome of low PTH after surgery and to monitor parathyroid recovery times in patients who underwent total thyroidectomy. Material and Methods: A commercially available PTH (iPTH) test was used to monitor iPTH levels on days ۱ and ۴. PTH levels were negative. It is determined by the same blood test as the sCa level. To exclude vitamin D deficiency, we first measured ۲۵-hydroxyvitamin D and ۱,۲۵-dihydroxyvitamin D levels in all patients Postoperative hypoparathyroidism was defined as postoperative albumin-adjusted sCa levels below ۱.۹ mmol/L (Convert to mg/dL, divide) with ۰.۲۵ (range of use, ۲.۱۰-۲.۶۰ mmol/L) symptoms of hypocalcemia (response to neuromuscular stress including paresthesias, muscle spasms, tetany or seizures) or sCa levels lower than results (۱.۹-۲.۱ mmol/L) with neuromuscular symptoms during the first ۴ days after surgery. Results: In a multivariate logistic regression model, we found that patients who received an autograft of parathyroid tissue during surgery were more likely to have low PTH immediately after surgery (OR = ۲.۶; ۹۵% CI, ۱.۸-۳.۸). Additionally, patients with parathyroid tissue who showed negative parathyroid tissue removal on the final pathology report were more likely to have postoperative PTH < ۱۰ pg/mL (OR = ۲.۲; ۹۵% CI, ۱.۵ -۳.۳). Parathyroid tissue was the only risk factor for permanent hypoparathyroidism in the pathology report (OR = ۳.۶, ۹۵% CI, ۱.۱–۱۱.۵). Conclusion: This study suggests that drug therapy should be considered in addition to PTH measurement, as ۵۰% of patients with persistent hypoparathyroidism have elevated PTH levels to ≥۱۰ pg/mL, but still want more help to avoid hypoparathyroidism. Symptoms of calcemia. In addition, ۱۲ months may be the most appropriate time to define persistent hypoparathyroidism, as ۵% of patients with low PTH resolve ۶-۱۲ months after treatment.کلیدواژه ها
risk factor, hypoparathyroidism, thyroidectomy, Predictorsاطلاعات بیشتر در مورد COI
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