Molecular Epidemiology of Hepatitis C Virus Infection― Status Quo and outlook

AbstractHepatitis C virus (HCV) infection has been a global health problem and, according to the recent report, more than ۷۱ million people (which equals to almost ۱% of population) have HCV infection. Onset of HCV infection is often acute and asymptomatic. In majority of cases, especially in underdeveloped countries, HCV infection remains undiagnosed for a long time. HCV has eight different genotypes, named from one to eight, which differ from each other at ۳۱%-۳۳% of nucleotides. Each genotype is further classified into several subtypes. Collectively, ۸۶ subtypes have been recognized which differ from each other at < ۱۵% nucleotide sequence. Determination of genotype of pathogen has been proven an effective means from the aspect of epidemiology. It is an important stage in the processes of decision-making and selecting appropriate therapeutic regimen. Studies have indicated that certain genotypes are found in countries or regions where direct acting antivirals are available against HCV infections. Developing awareness

کلیدواژه ها:

Molecular epidemiology ، Hepatitis C virus ، Genotype determination ، Nucleotides ، Awareness programs