Reza Bidaki - Research Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Bita Tavana - Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
Shima Hosseini - Kharazmi University, Tehran, Iran
Negar Neshati - School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Mojtaba Babaei Zarch - School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Introduction: Hypothyroidism is a common disorder of the endocrine system in which the production of thyroid hormones is inadequate. In addition to various physical manifestations, patients who suffer from hypothyroidism may also present with psychological problems, as described in previous studies. Case Presentation: Herein, the reports of ۲ patients who suffered from hypothyroidism and experienced improvement in their psychological symptoms after levothyroxine therapy are presented. The patients referred with depressive mood with psychotic features and psychomotor retardation. Treatment simultaneously with psychopharmacotherapy and hormone therapy was considered. Conclusion: Although hypothyroidism and depressive disorders are separate issues, hypothyroidism can induce depression and psychosis, and psychopharmacotherapy plus hormone therapy can be effective and boost treatment.

Hypothyroidism, Persecutory Delusion, Psychological Disturbance