Clinical Course of Henoch–Schönlein Purpura in South East of Iran

سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 139

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شناسه ملی سند علمی:

JR_INJPM-11-5_005

تاریخ نمایه سازی: 17 خرداد 1402

چکیده مقاله:

Background: The most prevalent form of systemic vasculitis in children is Henoch–Schönlein Purpura (HSP), also known as IgA vasculitis, with different manifestations. This study was performed to assess the clinical course of Henoch–Schönlein purpura in south east of Iran. Methods: The clinical data of ۲۲۱ children under age ۱۸ years who were diagnosed with HSP at Ali Ebne Abi Taleb hospital in Zahedan, Iran, was analyzed for a ten-year period. Clinical manifestations, laboratory measures and different types of treatments were recorded from the patients’ profiles with some useful additional information. Skin purpura, acute arthritis or arthralgia, gastrointestinal involvement, and renal involvement were the criteria for examination. Data description was performed by the use of SPSS ۲۳.۰۰. Results: Mean age of the patients was ۷.۳۷ ± ۳.۱۹ years at diagnosis and ۵۱.۱۳% of them were girls. About ۲۳.۸% and ۹۸.۶% of the patients had a history of upper respiratory infections and palpable purpura, respectively. Fever was detected in ۲۵.۲% of the children.  About ۲۸.۵% had vomiting and ۱۳.۶% had diarrhea. Renal involvement was observed in ۱۳۰ children. During the course of the disease, ۵۳.۸% received prednisolone and ۲۱.۷% received pulse methylprednisolone due to severe GI symptoms or renal involvement. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) were administered to ۱۹.۴۵% of the patients. Conclusion: The patients' sex ratio was close to ۱:۱, though girls slightly outnumbered boys. Most HSP patients had Joint symptoms, GI symptoms and renal involvement. Arthralgias were the initial manifestations. Multicenter prospective studies with a larger number of patients are recommended to confirm the results.

کلیدواژه ها:

Clinical course ، Henoch– Schö nlein purpura ، Children

نویسندگان

Simin Sadeghi-Bojd

Professore of pediatric nephrology, Children and Adolescents Health research center, Research Institute of cellular and Molecular Science in Infectious Diseases , Zahedan University of Medical Science&#۰۳۹;s, Zahedan, Iran.

Alireza Teimouri

Children and Adolescents Health research center, Research Institute of cellular and Molecular Science in Infectious Diseases , Zahedan University of Medical Science&#۰۳۹;s, Zahedan, Iran

Vahid Sheikhi

Pediatric Nephrologists, Pediatric Wards, Ali ebne Abitalib Hospital, School of Medicine, Zahedan University of Medical Science&#۰۳۹;s, Zahedan, Iran

Khadijeh Rashiodi Mehr

MD ,Razi Hospital in Saravan, Sistan and Baluchestan Province, Iran

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