Adel Baghersalimi - Pediatric Hematologist and Oncologist,: Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
Afagh Hassanzadeh rad - PHD of General Linguistics, Payame Noor University, Tehran, Iran. Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Shahin Koohmanaee - Pediatrics growth disorders research center, ۱۷ Shahrivar Hospital, pediatric department, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
bahram Darbandi - Pediatric Hematologist and Oncologist,: Pediatrics Growth Disorders Research Center, ۱۷th Sharivar Hospital, Guilan University of Medical Sciences, Rasht, Iran
Ehsan Kazemnejad-Leili - Associate Professor, Department of Biostatistics , Social Determinants of Health Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Rouzbeh Alishahi - Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Seyede Tahoura Hakemzadeh - Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Amir Mohammad Ghanbari - Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Setila Dalili - Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran

Background: This study aimed to assess whether weight gain predicts the outcome of childhood leukemia. Methods: This is a cohort study on patients with leukemia aged ۲ to ۱۹ years. Data was gathered by a form consisting of age, sex, baseline and final weight, height, Body Mass Index (BMI), and poor outcome (mortality plus occurrence). We used the Receiver Operator Characteristic (ROC) curve and the Area under the Curve (AUC) to define the cut-off points. Data analysis was performed in SPSS software version ۱۹. Results: ۱۱۴ patients enrolled in the study, including ۶۸ (۵۹.۶%) boys and ۴۶ (۴۰.۴%) girls. Ten patients (۸.۷%) died, and ۱۴ (۱۲.۲%) experienced a recurrence. Overall, ۱۶ (۱۴.۱%) patients had poor outcomes. In this study, most patients had annual weight gain (۹۵.۶%), and all had height gain. AUC of weight and height gain at the diagnosis and the end regarding poor outcome were ۰.۶۷۲ and ۰.۷۱۸, respectively. The cut-off points of weight and height gain for poor outcomes were ۱.۲ % per month (۱۴.۵% annual weight gain, and ۰.۳۲ % per month (۳.۸% annual height gain), respectively. Besides, ۶۰% of patients with weight loss had poor outcomes, and the results revealed that weight loss of more than ۱۲% per year causes poor outcomes. Conclusions: According to the results, weight and height gain during the treatment period can be related to a better outcome in children and adolescents with leukemia, irrespective of weight, height, and BMI at the diagnosis. Therefore, anthropometric indices may be associated with outcomes

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