Can Weight Gain Predict the Outcome of Childhood Leukemia?
- سال انتشار: 1402
- محل انتشار: مجله بین المللی کودکان، دوره: 11، شماره: 5
- کد COI اختصاصی: JR_INJPM-11-5_006
- زبان مقاله: انگلیسی
- تعداد مشاهده: 326
نویسندگان
Pediatric Hematologist and Oncologist,: Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
PHD of General Linguistics, Payame Noor University, Tehran, Iran. Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Pediatrics growth disorders research center, ۱۷ Shahrivar Hospital, pediatric department, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Pediatric Hematologist and Oncologist,: Pediatrics Growth Disorders Research Center, ۱۷th Sharivar Hospital, Guilan University of Medical Sciences, Rasht, Iran
Associate Professor, Department of Biostatistics , Social Determinants of Health Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
چکیده
Background: This study aimed to assess whether weight gain predicts the outcome of childhood leukemia. Methods: This is a cohort study on patients with leukemia aged ۲ to ۱۹ years. Data was gathered by a form consisting of age, sex, baseline and final weight, height, Body Mass Index (BMI), and poor outcome (mortality plus occurrence). We used the Receiver Operator Characteristic (ROC) curve and the Area under the Curve (AUC) to define the cut-off points. Data analysis was performed in SPSS software version ۱۹. Results: ۱۱۴ patients enrolled in the study, including ۶۸ (۵۹.۶%) boys and ۴۶ (۴۰.۴%) girls. Ten patients (۸.۷%) died, and ۱۴ (۱۲.۲%) experienced a recurrence. Overall, ۱۶ (۱۴.۱%) patients had poor outcomes. In this study, most patients had annual weight gain (۹۵.۶%), and all had height gain. AUC of weight and height gain at the diagnosis and the end regarding poor outcome were ۰.۶۷۲ and ۰.۷۱۸, respectively. The cut-off points of weight and height gain for poor outcomes were ۱.۲ % per month (۱۴.۵% annual weight gain, and ۰.۳۲ % per month (۳.۸% annual height gain), respectively. Besides, ۶۰% of patients with weight loss had poor outcomes, and the results revealed that weight loss of more than ۱۲% per year causes poor outcomes. Conclusions: According to the results, weight and height gain during the treatment period can be related to a better outcome in children and adolescents with leukemia, irrespective of weight, height, and BMI at the diagnosis. Therefore, anthropometric indices may be associated with outcomesکلیدواژه ها
leukemia,,, ,،child,,, ,،weight,,, ,،height,,, ,،body mass indexاطلاعات بیشتر در مورد COI
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