Transforming Growth Factor Β as a Marker of Hepatocellular Carcinoma in Patients with Chronic Hepatitis C Virus Infection
- سال انتشار: 1401
- محل انتشار: مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 11، شماره: 4
- کد COI اختصاصی: JR_RBMB-11-4_017
- زبان مقاله: انگلیسی
- تعداد مشاهده: 101
نویسندگان
Department of Internal Medicine, Faculty of Medicine, Aswan University, Egypt.
Nour El-Dean Abd-Elazeem Hefney
Department of Internal Medicine, Faculty of Medicine, Assuit University, Egypt.
Department of Clinical Pathology, Faculty of Medicine, Aswan University, Egypt.
Department of Medical Biochemistry, Faculty of Medicine, Aswan University, Egypt.
Department of Internal Medicine, Faculty of Medicine, Aswan University, Egypt.
چکیده
Background: The Transforming Growth Factor-beta (TGF-β) is one of the main growth factors associated with fibrosis or cirrhosis progression in the liver, but its role in hepatocarcinogenesis is controversial. To highlight the role of Transforming Growth Factor β as a marker of Hepatocellular carcinoma (HCC) in patients with chronic hepatitis C virus (HCV) infection. Methods: Ninety subjects were enrolled in this study, classified into three groups: Group I (chronic HCV group) included ۳۰ patients with chronic HCV infection; Group II (HCC group) include ۳۰ patients having HCC and chronic HCV infection and Group III consisted of ۳۰ age and sex-matched healthy controls. TGF-β was evaluated in all the enrollees and its levels were correlated to liver function and other clinical parameters. Results: TGF-β was found significantly higher in HCC group than in control and chronic HCV (P < ۰.۰۰۱). In addition, it was correlated with biochemical and clinical parameters of cancer. Conclusions: Patients with HCC showed increased level of TGF-β compared to chronic HCV infection patients and controls.کلیدواژه ها
Chronic HCV, Liver cirrhosis, Transforming Growth Factor β.اطلاعات بیشتر در مورد COI
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