Two-dimensional-Ti۳C۲ magnetic nanocomposite for targeted cancer chemotherapy

  • سال انتشار: 1401
  • محل انتشار: دومین کنگره ملی رویکردهای نوآورانه در سیستم بیولوژی و داروسازی
  • کد COI اختصاصی: IASBP02_035
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 207
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نویسندگان

Mahdieh Darroudi

Department of Physiology, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran Department of Medical Biotechnology and Nanotechnology, School of Science, Mashhad University of Medical Science, Mashhad, Iran Department of Electrical an

Seyedeh Elnaz Nazari

Department of Physiology, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran

Maryam Karimzadeh

Department of Medical Biotechnology and Nanotechnology, School of Science, Mashhad University of Medical Science, Mashhad, Iran

Fereshteh Asgharzadeh

Department of Physiology, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran

Nima Khalili-Tanha

Department of Physiology, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran

Seyyedeh Zahra Asghari

Department of Physiology, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran

چکیده

Cervical cancer is the primary cause of death among females. Traditional cancer treatments, such as chemotherapy, are often unsatisfactory because they involve invasive procedures, high recurrence rates, and side effects. Nanotechnology-based therapeutics are gaining increasing attention due to their multiple advantages, including a low level of invasiveness and few side-effects compared to other clinical treatments. The therapeutic route for nanoparticle-based therapies entails the delivery of nanoparticles to the tumor site, the treatment of the tumor with exogenous excitations, and the expulsion of nanoparticles from the body over time slowly. Therefore, for the first time, we investigated the effect of combining Ti۳C۲ nanosheets with magnetic core shells on the suppression of cervical cancer tumor growth in in vivo model.

کلیدواژه ها

drug delivery, cervix cancer, pH-responsive, magnetic nanocomposite, in-vivo, stimuli drug release

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