Frequency of HER۲ Expression, MMR Deficiency, and PI۳KCA Mutation in Pretreated Surgical Specimens of Patients with Esophageal Squamous Cell Carcinoma in Iran Cancer Institute

سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 102

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شناسه ملی سند علمی:

JR_IJP-18-1_011

تاریخ نمایه سازی: 26 اردیبهشت 1402

چکیده مقاله:

Background & Objective: Iran is located in the esophageal cancer geographical belt. As multiple genetic alterations are responsible for the molecular pathogenesis of esophageal squamous cell cancer (ESCC), the role and frequency of HER۲ expression, MMR deficiency, and PI۳KCA mutation are not well defined.Methods: We carried out HER۲/neu expression, dMMR/MSI high, and PI۳KCA mutation analysis in specimens of patients with ESCC. We accessed archival tissue blocks related to specimens of ۶۸ ESCC cases at the time of surgery following neoadjuvant chemoradiation. These patients underwent surgery during ۲۰۱۳-۲۰۱۸ at the Cancer Institute of Iran affiliated with the Tehran University of Medical Sciences in Tehran.Results: None of the patients showed HER۲ expression, dMMR/MSI high, or PI۳K mutations.Conclusion: dMMR/MSI-H and PI۳KCA mutation and HER۲ expression may not be reliable andfrequent targets for systemic therapy in patients with esophageal SCC.

نویسندگان

Samaneh Salarvand

Department of Clinical and Anatomical Pathology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Farzaneh Bagheri

Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Mahsa Gholizadeh

Radiation Oncology Research Center, Cancer Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Sima Sharifi

Department of Clinical and Anatomical Pathology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Pooneh Panahi

Department of Clinical and Anatomical Pathology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Ebrahim Esmati

Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Marzieh Lashkari

Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Amirmohsen Jalaeefar

Department of Oncosurgery, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Mohammad Shirkhoda

Department of Oncosurgery, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Reza Shahsiah

Department of Clinical and Anatomical Pathology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Reza Ghalehtaki

Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

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