Anti-inflammatory, immunomodulatory and anti-oxidant effects of Ocimum basilicum L. and its main constituents: A review
- سال انتشار: 1402
- محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 26، شماره: 6
- کد COI اختصاصی: JR_IJBMS-26-6_002
- زبان مقاله: انگلیسی
- تعداد مشاهده: 129
نویسندگان
Department of Biology, Faculty of Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
Department of Physiology, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
Pharmacognosy Group, Department of Pharmaceutical Biosciences, Biomedical Centre, Uppsala University, Uppsala, Sweden
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Ocimum basilicum L. (O. basilicum) is an ornamental and therapeutic plant with various pharmacological effects and medical applications. In this article, detailed information on the anti-oxidant, immunomodulatory, and anti-inflammatory properties of O. basilicum and its main constituents was provided. The literature survey of the different databases until the end of November ۲۰۲۱ was explored on the immunomodulatory, anti-inflammatory and anti-oxidant effects of the herb and its constituents. The plant and its constituents showed diverse pharmacological effects including immunomodulatory, anti-inflammatory and anti-oxidant properties by improving of the inflammatory mediators including interleukin (IL)-۱۰, IL-۴, tumor necrosis factor-alpha (TNF-α), interferon gamma (IFN-γ), nitric oxide (NO), serum levels of IFN-γ, IL۱۰ and IL-۴, IgG, IgM and phospholipase A۲ (PLA۲), immunoglobulin E (IgE), total protein (TP), oxidant and anti-oxidant markers. O. basilicum and its main constituents therefore, could be effective on the treatment of diseases associated with inflammation, immune dysregulation and oxidative stress. The present review article provides readers with organized information about the anti-oxidant, immunomodulatory, and anti-inflammatory properties of O. basilicum.کلیدواژه ها
Anti-Oxidants, Basil extract, Inflammation, Immunomodulation, Ocimum basilicumاطلاعات بیشتر در مورد COI
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