Evaluation of rs۷۹۰۳۱۴۶ Polymorphism in TCF۷L۲ Gene among Type ۲ Diabetes Patients
- سال انتشار: 1401
- محل انتشار: فصلنامه بین المللی تحقیقات پزشکی، دوره: 11، شماره: 4
- کد COI اختصاصی: JR_INTJMI-11-4_014
- زبان مقاله: انگلیسی
- تعداد مشاهده: 331
نویسندگان
Biotechnology Research Center (BRC), Pasteur Institute of Iran, Tehran, Iran, Department of Biotechnology, Islamic Azad University, Central Tehran Branch, Tehran, Iran
Department of Chemistry, Faculty of Science, Ataturk University, Erzurum, ۲۵۲۴۰, Turkey
Department of Medicine, Pirogov Russian National Research Medical University, Moscow, Russia
Department of Midwifery, Health Center of Maragheh, Maragheh, East Azerbaijan, Iran, Department of Genetics, Islamic Azad University of Bonab, Bonab, East Azerbaijan, Iran
Department of Pharmacology, Guilan University of Medical Sciences, Rasht, Guilan, Iran
Department of Microbiology, Islamic Azad University of Maragheh, Maragheh, East Azerbaijan, Iran
Department of Medicine, Medical University of Ilam, Ilam, Iran
چکیده
Background: Diabetes is characterized by decreased insulin sensitivity and is a growing health threat worldwide. Therefore, this study aimed to evaluate the relationship between rs۷۹۰۳۱۴۶ polymorphism in the TCF۷L۲ gene with type ۲ diabetes in East Azerbaijan province, Iran. Materials and method: A total of ۱۰۰ blood samples were collected from diabetic and healthy people. The samples were subjected to specific primers, PCR, and electrophoresis after DNA extraction from all samples and quality control. Finally, the PCR products were treated with RSal restriction enzyme and electrophoresed again, and the target polymorphism was checked. Results: The frequency of genotypes were TT=۳۳.۷%, CC=۱۶.۸% and CT=۴۹.۵% for healthy people and TT=۴۳%, CC=۱۴% and TC=۴۳% in diabetics. The percentage of the T allele in healthy and diabetic people was as much as ۴۲.۱% and ۶۴.۵%, respectively. Conclusion: According to the results, there was probably a relationship between rs۷۹۰۳۱۴۶ polymorphism in the TCF۷L۲ gene and diabetes.کلیدواژه ها
Polymorphism, rs۷۹۰۳۱۴۶, TCF۷L۲, Type ۲ diabetesاطلاعات بیشتر در مورد COI
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