Correlation Between the Bacterial and Fungal Profiles from the Clinical Specimens with the CD۴ Counts and the NLR Values of HIV/AIDS Patients at Tertiary Referral Hospital in Indonesia
- سال انتشار: 1402
- محل انتشار: مجله علوم دارویی و شیمی، دوره: 6، شماره: 9
- کد COI اختصاصی: JR_JMCH-6-9_018
- زبان مقاله: انگلیسی
- تعداد مشاهده: 185
نویسندگان
Study Program of Clinical Microbiology Specialist, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
Department of Medical Microbiology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
Department of Medical Microbiology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
چکیده
Human immunodeficiency virus (HIV) poses a significant problem for the global public health with high morbidity and mortality rates. HIV/AIDS cases in Indonesia, the country with the fifth highest risk of HIV/AIDS in Asia, continue to increase. A decrease in CD۴ levels indicates an increase in the opportunistic infection rates of HIV patients. In addition, Neutrophil to Lymphocyte Ratio (NLR) can serve as the basis for bacterial infection, infection rate, and antibiotic therapy. This observational analytic study applies a retrospective cross-sectional design and aims to observe the correlation between bacterial and fungal profiles of clinical specimens and the CD۴ cell counts and the NLR values of HIV/AIDS inpatients at Dr. Soetomo Tertiary Referral Hospital from September ۲۰۲۱ to August ۲۰۲۲. A total of ۱۹۲ bacterial and fungal identification test results from ۷۶ patients were collected, consisting of ۸۳.۳% bacterial culture tests, consisting of ۵۲.۵% negative cultures, ۱۲% gene expert TB tests, and ۴.۷% fungal culture tests. Pseudomonas aeruginosa and Escherichia coli ESBL were the highest numbers of Gram-negative bacteria found in this study, amounting to ۵۱.۳۳%, followed by Streptococcus viridans, the highest number of Gram-positive bacteria found in this study, amounting to ۴۸.۶۷%. A total of ۳۴.۲% commensal bacteria and ۲۱.۰۵% Multi-Drug Resistant Organism (MDRO) bacteria were also found in this study. The gene expert TB tests resulted in ۷۳.۹% undetected M. tuberculosis, while the fungal culture tests resulted in ۸۸.۹% Candida albicans. Furthermore, there was no correlation between the bacterial and fungal profiles from clinical specimens with CD۴ counts or NLR values in HIV/AIDS-infected patients.کلیدواژه ها
HIV, bacterial profiles, fungal profiles, CD۴, NLR, Opportunistic infectionsاطلاعات بیشتر در مورد COI
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