A Comparison of Efficacy and Adverse Effects of Cetirizine and Desloratadine in ۶-۱۲-Year-Old Children with Allergic Rhinitis
- سال انتشار: 1402
- محل انتشار: مجله بین المللی کودکان، دوره: 11، شماره: 4
- کد COI اختصاصی: JR_INJPM-11-4_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 281
نویسندگان
Neonatal Research Center, Shiraz University of Medical Science, Shiraz, Iran
Department of Pediatrics, Shiraz University of Medical Science, Shiraz, Iran
Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
mohammadreza Samadzadeh Mamaghani
Department of pharmacology, Faculty of Veterinary Medicine, University of Tehran, Iran
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
University of Arizona, Tucson, AZ ۸۵۷۲۱, USA
چکیده
Background: Antihistamines are the most common drugs used for treating allergic rhinitis. They, significantly, reduce nasal symptoms by blocking the action of a chemical cytokine called histamine. This study aimed to compare cetirizine and desloratadine's efficacy and adverse effects in children with allergic rhinitis.Method: This randomized single-blinded clinical trial was conducted on ۴۰۰ children with allergic rhinitis, aged ۶-۱۲ between February and September ۲۰۲۲. The patients were randomized to receive cetirizine or desloratadine for four weeks. We recorded the symptoms and adverse effects at the baseline and four weeks after starting the intervention.Results: A total of ۲۴۸ patients completed the study: ۱۰۹ patients (۴۷ female, ۶۲ male) in the cetirizine group and ۱۳۹ patients (۵۳ female, ۸۶ male) in the desloratadine group. The scores related to symptoms of allergic rhinitis before starting the drugs and after ۴-week therapy were not significantly different between the two treatment groups (p= ۰.۱, p= ۰.۷, respectively). Cetirizine had more side effects than desloratadine in the treated patients (p = ۰.۰۲).Conclusion: This study showed that cetirizine and desloratadine improved symptoms of children with allergic rhinitis; however, there was no significant difference in the efficacy of these two drugs. Desloratadine caused fewer side effects in patients after ۴ weeks of treatment.کلیدواژه ها
Cetirizine,,, ,،Desloratadine,,, ,،Allergic rhinitis,,, ,،Histamine antagonistsاطلاعات بیشتر در مورد COI
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