Oral Ketamine or Nasal Midazolam for Sedation in Pediatric Upper Gastrointestinal Endoscopy
محل انتشار: علوم اعصاب کاسپین، دوره: 9، شماره: 2
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 115
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شناسه ملی سند علمی:
JR_CJNS-9-2_004
تاریخ نمایه سازی: 9 اردیبهشت 1402
چکیده مقاله:
Background: There is no agreement on the route of administration and the drug of choice for providing adequate sedation for pediatric invasive procedures.
Objectives: We compared the utility, safety, and sedation effects of intranasal midazolam and oral ketamine.
Materials & Methods: This double-blind clinical trial was performed on ۱۰۰ children aged ۲ to ۱۴ years who were candidates for upper gastrointestinal (GI) endoscopy. Patients were randomly assigned to two groups: ketamine (۴ mg/kg orally) and midazolam (۰.۱ mg/ kg intranasal). Sedation score, fear levels, children’s behavior at the time of separation from parents, and vital signs were recorded.
Results: Higher systolic blood pressure was seen in children who received ketamine (P=۰.۰۱۲) and lower arterial oxygen saturation in the midazolam group (P=۰.۰۲۳). Also, the level of sedation showed no significant difference between the groups.
Conclusion: Based on the results, administering oral ketamine or intranasal midazolam before endoscopy induced a similar sedation score in children. Also, both methods could be safe and non-invasive modalities for sedation.
کلیدواژه ها:
نویسندگان
Shohreh Maleknejad
Pediatric Disease Research Center, Guilan University of Medical Sciences, Rasht, Iran
Farnoush Farzi
Department of Anesthesiology, Anesthesiology Research Center, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran
Abtin Heidarzadeh
Medical Education Research Center, Guilan University of Medical Sciences, Rasht, Iran
Afshin Safaei Asl
Pediatric Disease Research Center, Guilan University of Medical Sciences, Rasht, Iran
Afagh Hasanzadeh Rad
Pediatric Disease Research Center, Guilan University of Medical Sciences, Rasht, Iran
Seyyedeh Azade Hoseini Nouri
Pediatric Disease Research Center, Guilan University of Medical Sciences, Rasht, Iran