Interaction of copper oxide nanoparticles with bacterial nucleic acids: a mini-review

  • سال انتشار: 1402
  • محل انتشار: مجله جنبه های زیستی میکرو نانو، دوره: 2، شماره: 1
  • کد COI اختصاصی: JR_MNBA-2-1_003
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 137
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نویسندگان

Mehran Alavi

Department of Biological Science, Faculty of Science, University of Kurdistan, Sanandaj, Kurdistan, Iran Nanobiotechnology Department, Faculty of Innovative Science and Technology, Razi University, Kermanshah, Iran

Michael Hamblin

Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, ۲۰۲۸, South Africa Wellman Centre for Photomedicine, Massachusetts General Hospital, Boston, MA ۰۲۱۱۴, USA Department of Dermatology, Harvard

چکیده

Despite the wide use of conventional antibiotics to treat bacterial infections, bacteria have now become resistant to many antibiotics and other antibacterial agents. This resistance is heritable and allows the spread of intractable bacterial infections, which is one of the biggest health challenges encountered around the world. This issue has led to the search for new therapeutic antibacterial agents. In the last few decades, nanomaterials, especially metal and metal oxide nanoparticles (NPs), have gained much attention due to their advantageous properties, including large surface-to-volume ratio and high antimicrobial activity. Among various metal and metal oxide NPs, copper oxide NPs have been particularly investigated owing to their biocompatibility and antibacterial activity against both Gram-positive and Gram-negative bacteria. Several antibacterial mechanisms have been proposed for copper oxide NPs, among which their interaction with bacterial deoxyribonucleic acid and ribonucleic acid is considered important. These NPs can disrupt the accuracy of DNA replication by changing the DNA sequence which result in differences in the target sequences bound by random amplification of polymorphic DNA (RAPD) primers. This mini-review discusses this interaction according to recent studies.

کلیدواژه ها

Antibacterial mechanisms, Biocompatibility, Deoxyribonucleic Acid, Infectious Diseases, Ribonucleic acid, Therapeutic strategies

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