The Study Histopathological Changes Tissues In Dermal Toxicity of Nanosilver
- سال انتشار: 1387
- محل انتشار: دومین کنگره بین المللی علوم و فناوری نانو
- کد COI اختصاصی: ICNN02_642
- زبان مقاله: انگلیسی
- تعداد مشاهده: 855
نویسندگان
Department of pharmacology s, University medical science, Tehran
Department of pharmaceutics, Faculty of medicine, University of medical science
چکیده
Silver is a relatively rare metal that occurs naturally in the earth's crust and is released to the environment from various industrial sources. Human exposure to silver and silver compounds can occur orally, dermally, or by inhalation. Silver is found in most tissues, but has no known physiologic function. In humans, accidental or intentional ingestion of large doses of silver nitrate has produced corrosive damage of the gastrointestinal tract, abdominal pain, diarrhea, vomiting, shock, convulsions, and death [1]. Respiratory irritation was noted following acute inhalation exposure to silver or silver compounds. Silver nitrate solutions are highly irritating to the skin, mucous membranes, and eyes [2].The colloidal nanosilver solution of the present invention can be used in sanitary products, solutions for cleansing agents for clothing also be used in health care products, treating patients with all kinds of injuries and/or burns, bacterial and fungal infections, gastrointestinal bacterial infection, and sexually transmitted diseases. [3]No macroscopic changes in skin were observed, but there were histopathological changes in tissues. In control group, tissues were completely normal but there were some inflammation in other groups. As a result, the most histopathological changes were in the nanosilver concentration of 10000 ppm compared to other concentration. Thus high concentration has direct relationship with the observed changes. In this study, limitations were consisting the lack of enough nanosilver and sensitive animals.کلیدواژه ها
nanosilver, dermal toxicity ,histopathological changesمقالات مرتبط جدید
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.