Preparation of Chitosan Nanoparticles Loaded By Desferrioxamine

Desferrioxamine is an iron chelator extensively used in thalassemic patients to manage their iron overstorage. The drug is now routinely administered subcutaneously, every 8 to 12 hours, which exert some serious problems to the patients leading to the poor patient compliance. Chitosan, the deacetylated derivative of chitin, is one of the abundant, renewable, nontoxic and biodegradable carbohydrate polymers available largely in the exoskeletons of shellfish and insects. Recently, hydrogel nanoparticles have gained remarkable attention in drug delivery, owing to their hydrophilicity, small particle sizes, ease of preparation, and biocompatibility, among other advantages.