Endoscopic Findings and Histopathological Patterns of Gastric Mucosal Biopsies in Functional Dyspepsia: A Clinicopathological Study

  • سال انتشار: 1402
  • محل انتشار: مجله دانشگاه علوم پزشکی کرمان، دوره: 30، شماره: 1
  • کد COI اختصاصی: JR_JKMU-30-1_001
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 184
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نویسندگان

Mohammad Mahdi Hayatbakhsh Abbasi

Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

Elham Jafari

Pathology and Stem Cells Research Center, Pathology Department, Kerman University of Medical Sciences, Kerman, Iran

Mohamad Javad Zahedi

Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

Sodaif Darvish Moghaddam

Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

Reza Malekpoor Afshar

Pathology and Stem Cells Research Center, Pathology Department, Kerman University of Medical Sciences, Kerman, Iran

Mohadese Sadat Saeedi

Faculty of Medicine, Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran

Roya Pooyan Fard

Psychiatric Resident, Psychiatry Department, Shahid Beheshti Hospital, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

چکیده

Background: Endoscopic examination of the gastrointestinal tract through macroscopic and histopathological evaluation provides a tool to differentiate the major causes of functional dyspepsia. The distinction is not always clear. This study aimed to assess the frequency and type of the macroscopic and histopathological changes in gastrointestinal tract endoscopy in patients with symptoms of functional dyspepsia. Methods: A cross-sectional study was performed on ۹۷ patients aged ۱۰–۸۵ years who underwent gastroscopy due to functional dyspepsia symptoms. The patients had no history of weight loss, major comorbidities like diabetes or cirrhosis, non-steroidal anti- inflammatory drug (NSAID) consumption, peptic ulcer, or any other confounding causes. Biopsy specimens were taken from the stomach and duodenum for histopathological examination. The presence of Helicobacter pylori infection was established based on histopathological examination and a positive rapid urease test.Results: Gastric biopsies of ۹۷ patients with functional dyspepsia were studied. In histological examination of gastric mucosal biopsies, chronic inflammation was present in ۹۴ (۹۶.۹%), activity was seen in ۴۷ (۴۸.۵%), glandular atrophy was seen in ۳ (۳.۱%), and intestinal metaplasia was seen in ۹ (۹.۲%) patients. H. pylori was identified on gastric mucosal biopsies in ۴۶ (۴۷.۴%) patients based on sections stained with H&E and Giemsa.Conclusion: According to the obtained results, it is concluded that patients with functional dyspepsia have a higher frequency of gastric mucosal inflammation and H. pylori infection.

کلیدواژه ها

Keywords: Endoscopy, Functional dyspepsia, Gastric mucosa, Histopathologic features

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